Literature DB >> 25061057

Chronic brain hypoperfusion due to multi-vessel extracranial atherosclerotic disease: a potentially reversible cause of cognitive impairment.

Apostolos Safouris1, Anne-Sophie Hambye2, Claudine Sculier1, Sokratis G Papageorgiou3, Spyros N Vasdekis4, Marie-Dominique Gazagnes1, Georgios Tsivgoulis5.   

Abstract

A 62-year-old patient presented with persistent cognitive deficits 3 months after a right temporal ischemic stroke due to ipsilateral carotid occlusion. Work-up disclosed hemodynamically significant contralateral carotid artery stenosis and left subclavian steal phenomenon. Brain SPECT imaging revealed bihemispheric chronic brain hypoperfusion that substantially improved on repeat imaging when the subclavian steal was temporarily diminished by inflating a cuff around the left arm. Carotid endarterectomy of the asymptomatic carotid stenosis substantially ameliorated bihemispheric brain perfusion and reversed cognitive impairment. This case highlights that multi-vessel, extracranial atherosclerotic disease may cause chronic diffuse brain hypoperfusion that can be associated with cognitive impairment.

Entities:  

Keywords:  Asymptomatic carotid stenosis; SPECT; carotid endarterectomy; chronic brain hypoperfusion; subclavian steal; transcranial Doppler

Mesh：

Year:  2015        PMID： 25061057     DOI： 10.3233/JAD-141203

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  9 in total

1.  The Alzheimer's Prevention Clinic at Weill Cornell Medical College / New York - Presbyterian Hospital: Risk Stratification and Personalized Early Intervention.

Authors:  A Seifan; R Isaacson
Journal:  J Prev Alzheimers Dis       Date:  2015-10-01

Review 2.  Advances in chronic cerebral circulation insufficiency.

Authors:  Da Zhou; Ran Meng; Si-Jie Li; Jing-Yuan Ya; Jia-Yue Ding; Shu-Ling Shang; Yu-Chuan Ding; Xun-Ming Ji
Journal:  CNS Neurosci Ther       Date:  2017-11-15       Impact factor: 5.243

3.  Icariside II affects hippocampal neuron axon regeneration and improves learning and memory in a chronic cerebral hypoperfusion rat model.

Authors:  Tao Liu; Fang He; Jiahong Yan; Wei Kuang; Changyin Yu
Journal:  Int J Clin Exp Pathol       Date:  2019-03-01

Review 4.  Carotid Atherosclerosis and Cognitive Impairment in Nonstroke Patients.

Authors:  Wei-Hong Chen; Wei Jin; Pei-Yuan Lyu; Yang Liu; Rui Li; Ming Hu; Xiang-Jian Xiao
Journal:  Chin Med J (Engl)       Date:  2017-10-05       Impact factor: 2.628

5.  Midterm Blood Pressure Variability Is Associated with Poststroke Cognitive Impairment: A Prospective Cohort Study.

Authors:  Shan Geng; Na Liu; Pin Meng; Niu Ji; Yong'an Sun; Yingda Xu; Guanghui Zhang; Xiaobing He; Zenglin Cai; Bei Wang; Bei Xu; Zaipo Li; Xiaoqin Niu; Yongjin Zhang; Bingchao Xu; Xinyu Zhou; Mingli He
Journal:  Front Neurol       Date:  2017-07-28       Impact factor: 4.003

Review 6.  Safety and Clinical Efficacy of Yangxue Qingnao Granules in the Treatment of Chronic Cerebral Circulation Insufficiency: A Systematic Review and Meta-Analysis.

Authors:  Jianbo Guo; Xingjiang Xiong; Yu Cao; Yukun Ding; Qingyong He
Journal:  Evid Based Complement Alternat Med       Date:  2019-08-14       Impact factor: 2.629

7.  The effect of chronic cerebral hypoperfusion on the pathology of Alzheimer's disease: A positron emission tomography study in rats.

Authors:  Jae-Hyung Park; Jeong-Ho Hong; Sang-Woo Lee; Hyun Dong Ji; Jung-Ah Jung; Kyung-Wha Yoon; Jung-In Lee; Kyoung Sook Won; Bong-Il Song; Hae Won Kim
Journal:  Sci Rep       Date:  2019-10-01       Impact factor: 4.379

8.  Selective neurodegeneration of the hippocampus caused by chronic cerebral hypoperfusion: F-18 FDG PET study in rats.

Authors:  Jung-In Lee; Ji Sun Lim; Jeong-Ho Hong; Shin Kim; Sang-Woo Lee; Hyun Dong Ji; Kyoung Sook Won; Bong-Il Song; Hae Won Kim
Journal:  PLoS One       Date:  2022-02-10       Impact factor: 3.240

Review 9.  Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment.

Authors:  Vismitha Rajeev; David Y Fann; Quynh Nhu Dinh; Hyun Ah Kim; T Michael De Silva; Mitchell K P Lai; Christopher Li-Hsian Chen; Grant R Drummond; Christopher G Sobey; Thiruma V Arumugam
Journal:  Theranostics       Date:  2022-01-16       Impact factor: 11.556
  9 in total

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