Y Dong1, W-P Wang, J Cao, P Fan, X Lin. 1. Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.
Abstract
OBJECTIVE: We performed a prospective study to evaluate the value of contrast-enhanced (CE) ultrasound in quantitative evaluation of renal cortex perfusion in patients with chronic kidney dysfunction (CKD Stage I-II). METHODS: The present study was approved by the institutional ethics committee. The study focused on 41 consecutive patients (males, 32; females, 9; mean age, 55.0 ± 5.0 years) with clinical suspicion of CKD (Stages I-II). For both kidneys, CE ultrasound was performed after intravenous bolus injection of 1.0 ml SonoVue® (Bracco Imaging S.p.A., Milan, Italy). Time-intensity curves (TICs) and quantitative indexes were created with Qlab software (Philips, Bothell, WA). 45 healthy volunteers were included as control group. All statistical analyses were performed with SPSS® v. 15.0 software package (SPSS, Chicago, IL). A difference was considered statistically significant with p < 0.05. RESULTS: Patients with CKD (Stages I-II) had no obvious change in the shape of TICs. Among all quantitative indexes, the changes of area under the curve (AUC), derived peak intensity (DPI) and slope rate of elevation curve (A) were statistically significant (p < 0.05). DPI <12 dB, A >2 and AUC >1300 dB s had high utility in the evaluation of CKD, with 81%, 73% and 78% specificities and 76%, 73% and 77% sensitivities. CONCLUSION: CE ultrasound might be valuable in the early evaluation of CKD. AUC, A and DPI might be valuable quantitative indexes. ADVANCES IN KNOWLEDGE: Quantitative CE ultrasound analysis can be used for the standardized and early evaluation of renal dysfunction.
OBJECTIVE: We performed a prospective study to evaluate the value of contrast-enhanced (CE) ultrasound in quantitative evaluation of renal cortex perfusion in patients with chronic kidney dysfunction (CKD Stage I-II). METHODS: The present study was approved by the institutional ethics committee. The study focused on 41 consecutive patients (males, 32; females, 9; mean age, 55.0 ± 5.0 years) with clinical suspicion of CKD (Stages I-II). For both kidneys, CE ultrasound was performed after intravenous bolus injection of 1.0 ml SonoVue® (Bracco Imaging S.p.A., Milan, Italy). Time-intensity curves (TICs) and quantitative indexes were created with Qlab software (Philips, Bothell, WA). 45 healthy volunteers were included as control group. All statistical analyses were performed with SPSS® v. 15.0 software package (SPSS, Chicago, IL). A difference was considered statistically significant with p < 0.05. RESULTS:Patients with CKD (Stages I-II) had no obvious change in the shape of TICs. Among all quantitative indexes, the changes of area under the curve (AUC), derived peak intensity (DPI) and slope rate of elevation curve (A) were statistically significant (p < 0.05). DPI <12 dB, A >2 and AUC >1300 dB s had high utility in the evaluation of CKD, with 81%, 73% and 78% specificities and 76%, 73% and 77% sensitivities. CONCLUSION: CE ultrasound might be valuable in the early evaluation of CKD. AUC, A and DPI might be valuable quantitative indexes. ADVANCES IN KNOWLEDGE: Quantitative CE ultrasound analysis can be used for the standardized and early evaluation of renal dysfunction.
Authors: Jörg Radermacher; Michael Mengel; Sebastian Ellis; Stephan Stuht; Markus Hiss; Anke Schwarz; Ute Eisenberger; Michael Burg; Friedrich C Luft; Wilfried Gwinner; Hermann Haller Journal: N Engl J Med Date: 2003-07-10 Impact factor: 91.245
Authors: Carolien S E Bulte; Jeroen Slikkerveer; Rick I Meijer; Dennis Gort; Otto Kamp; Stephan A Loer; Stefano F de Marchi; Rolf Vogel; Christa Boer; R Arthur Bouwman Journal: Anesth Analg Date: 2012-02-24 Impact factor: 5.108
Authors: Antoine G Schneider; Lucie Hofmann; Grégoire Wuerzner; Nicolas Glatz; Marc Maillard; Jean-Yves Meuwly; Philippe Eggimann; Michel Burnier; Bruno Vogt Journal: Nephrol Dial Transplant Date: 2011-06-20 Impact factor: 5.992
Authors: Francesco Maria Drudi; Vito Cantisani; Antonio Granata; Flavia Angelini; Daniela Messineo; Carlo De Felice; Evaristo Ettorre Journal: J Ultrasound Date: 2019-06-13
Authors: E Stock; D Paepe; S Daminet; E Vandermeulen; L Duchateau; J H Saunders; K Vanderperren Journal: J Vet Intern Med Date: 2017-11-24 Impact factor: 3.333
Authors: E Stock; S Daminet; D Paepe; E Buresova; E Vandermeulen; P Smets; L Duchateau; J H Saunders; K Vanderperren Journal: J Vet Intern Med Date: 2017-10-14 Impact factor: 3.333