Emilia Hagman 1 , Perna Ighani Arani 2 , Manjula Fischer 1 , Pernilla Danielsson 1 , Katarzyna Marcinkiewicz 2 , Elzbieta Petriczko 2 , Claude Marcus 1 . Show Affiliations »
Abstract
AIM: An elevated fasting glucose level is an early sign of metabolic dysfunction in obese children. This study compared fasting glucose levels in obese young children in Poland and Sweden. METHODS: We identified 109 obese children aged between two and 10 years from a Polish obesity register, with a mean BMI SDS (SD) of 3.72 (0.86). Each Polish child was matched by gender, age and degree of obesity, with ten children (n = 1090) from BORIS, the Swedish national childhood obesity treatment register. A group of 86 Swedish nonobese children served as controls. RESULTS: The mean fasting glucose values of the Polish, Swedish and nonobese cohorts were 4.73 (0.51) mmol/L, 4.92 (0.50) mmol/L and 4.56 (0.39) mmol/L, respectively. After adjusting for variables affecting fasting glucose, the mean glucose value of the Swedish obese children was 0.20 mmol/L higher than that of Polish obese children (p < 0.0001) and 0.41 mmol/L higher than in nonobese controls (p < 0.0001). CONCLUSION: Swedish obese young children had higher glucose levels than Polish obese young children. This suggests that Swedish obese children face a higher risk of the prediabetic stage impaired fasting glycaemia. ©2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
AIM: An elevated fasting glucose level is an early sign of metabolic dysfunction in obese children . This study compared fasting glucose levels in obese young children in Poland and Sweden. METHODS: We identified 109 obese children aged between two and 10 years from a Polish obesity register, with a mean BMI SDS (SD) of 3.72 (0.86). Each Polish child was matched by gender, age and degree of obesity , with ten children (n = 1090) from BORIS , the Swedish national childhood obesity treatment register. A group of 86 Swedish nonobese children served as controls. RESULTS: The mean fasting glucose values of the Polish, Swedish and nonobese cohorts were 4.73 (0.51) mmol/L, 4.92 (0.50) mmol/L and 4.56 (0.39) mmol/L, respectively. After adjusting for variables affecting fasting glucose , the mean glucose value of the Swedish obese children was 0.20 mmol/L higher than that of Polish obese children (p < 0.0001) and 0.41 mmol/L higher than in nonobese controls (p < 0.0001). CONCLUSION: Swedish obese young children had higher glucose levels than Polish obese young children . This suggests that Swedish obese children face a higher risk of the prediabetic stage impaired fasting glycaemia . ©2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
Entities: Chemical
Disease
Gene
Species
Keywords:
Childhood obesity; Epidemiology; Glucose; Insulin
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Year: 2014
PMID: 25060480 DOI: 10.1111/apa.12760
Source DB: PubMed Journal: Acta Paediatr ISSN: 0803-5253 Impact factor: 2.299