Yu Li1, Peizhun Du1, Yangbing Zhou2, Qiushi Cheng3, Dong Chen1, Dongsheng Wang1, Teng Sun1, Jinzhe Zhou1, Rajan Patel1. 1. Department of General Surgery, Affiliated Hospital to Medical College of Qingdao University, Qingdao, China. 2. Department of General Surgery, Affiliated Hospital to Medical College of Qingdao University, Qingdao, China. Electronic address: zhouyanbing999@126.com. 3. Department of Health Care, Qingdao municipal Hospital (East), Qingdao, China.
Abstract
BACKGROUND: There is no consensus as to the impact of lymph node micrometastases (LNMM) on survival of patients with gastric cancer. The aim of this analysis was to investigate the prognostic significance of LNMM in patients with histologic node-negative gastric cancer. METHODS: We searched relevant studies from PubMed, Embase, and the Cochrane Library (1966-2013.5), used software STATA 12.0 to pool the outcomes of each study. Mantel-Haenszel and Inverse Variance methods were used in a fixed effect model and a random effect model, respectively. The hazard ratios (HR) and odds risk (OR) at their 95% confidence intervals (CIs) were used as measures to investigate the prognostic importance of LNMM, by searching for a correlation between the clinical pathologic features and LNMM. RESULTS: Our analysis of 18 eligible studies revealed that patients with LNMM had an increased likelihood of having a worse 5-y survival rate (HR 2.81; 95% CI: 1.96-4.02). Subgroup analyses showed a more significant result for patients in pT1-2N0 (HR 3.52; 95% CI 1.88-6.62). The analyses also revealed that (OR 1.32; 95% CI 1.17-1.48), lymphatic invasion (OR 2.21; 95% CI 1.42-3.44) and venous invasion (OR 1.41; 95% CI 1.08-1.85) were associated with the occurrence of LNMM. CONCLUSIONS: There is a positive correlation between LNMM and an unfavorable surgical outcome in gastric cancer. Undifferentiated histologic findings, lymphatic invasion, and venous invasion are high risk factors for the occurrence of LNMM.
BACKGROUND: There is no consensus as to the impact of lymph node micrometastases (LNMM) on survival of patients with gastric cancer. The aim of this analysis was to investigate the prognostic significance of LNMM in patients with histologic node-negative gastric cancer. METHODS: We searched relevant studies from PubMed, Embase, and the Cochrane Library (1966-2013.5), used software STATA 12.0 to pool the outcomes of each study. Mantel-Haenszel and Inverse Variance methods were used in a fixed effect model and a random effect model, respectively. The hazard ratios (HR) and odds risk (OR) at their 95% confidence intervals (CIs) were used as measures to investigate the prognostic importance of LNMM, by searching for a correlation between the clinical pathologic features and LNMM. RESULTS: Our analysis of 18 eligible studies revealed that patients with LNMM had an increased likelihood of having a worse 5-y survival rate (HR 2.81; 95% CI: 1.96-4.02). Subgroup analyses showed a more significant result for patients in pT1-2N0 (HR 3.52; 95% CI 1.88-6.62). The analyses also revealed that (OR 1.32; 95% CI 1.17-1.48), lymphatic invasion (OR 2.21; 95% CI 1.42-3.44) and venous invasion (OR 1.41; 95% CI 1.08-1.85) were associated with the occurrence of LNMM. CONCLUSIONS: There is a positive correlation between LNMM and an unfavorable surgical outcome in gastric cancer. Undifferentiated histologic findings, lymphatic invasion, and venous invasion are high risk factors for the occurrence of LNMM.
Authors: Peng Ding; Chen Zheng; Guohui Cao; Ziming Gao; Yuying Lei; Peng Deng; Bin Hou; Kai Li Journal: Cancer Med Date: 2019-05-02 Impact factor: 4.452
Authors: Fernando A V Santos; Ana P Drummond-Lage; Alberto J A Wainstein; Marco A Dias-Filho; Paulo R Savassi-Rocha; Tulio P Navarro Journal: Sci Rep Date: 2020-02-24 Impact factor: 4.379