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Literature DB >> 2505749

Glucocorticoids modulate mRNA levels for G-protein beta-subunits.

M Ros¹, D C Watkins, P J Rapiejko, C C Malbon.

Abstract

Adrenalectomy decreases, whereas glucocorticoid treatment increases, the steady-state levels of G-protein beta-subunits (G beta) in rat fat-cells. A DNA-excess solution-hybridization assay was established to define the steady-state mRNA levels for G beta [5.8 +/- 0.4 amol/micrograms of RNA (n = 5) in control fat-cells]. G beta mRNA levels decrease by 20% after adrenalectomy; dexamethasone treatment reverses the decline. Dexamethasone treatment itself increases G beta mRNA levels by 50%.

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Year: 1989 PMID： 2505749 PMCID： PMC1138656 DOI： 10.1042/bj2600271

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

28 in total

Review 1. Permissive hormone regulation of hormone-sensitive effector systems.

Authors: C C Malbon; P J Rapiejko; D C Watkins
Journal: Trends Pharmacol Sci Date: 1988-01 Impact factor: 14.819

2. Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide-binding proteins serving as the substrate of islet-activating protein, pertussis toxin.

Authors: T Katada; M Oinuma; M Ui
Journal: J Biol Chem Date: 1986-04-15 Impact factor: 5.157

Glucocorticoids modulate mRNA levels for G-protein beta-subunits.

Review 1. Permissive hormone regulation of hormone-sensitive effector systems.

2. Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide-binding proteins serving as the substrate of islet-activating protein, pertussis toxin.

3. Purification of the major GTP-binding proteins from human placental membranes.

4. Cloning of a portion of the chromosomal gene for human erythrocyte alpha-spectrin by using a synthetic gene fragment.

Review 5. Steroid receptor regulated transcription of specific genes and gene networks.

6. G proteins and dual control of adenylate cyclase.

7. Fat cell adenylate cyclase system. Enhanced inhibition by adenosine and GTP in the hypothyroid rat.

8. Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

9. DNA sequencing with chain-terminating inhibitors.

10. Hypothyroidism modulates beta adrenergic receptor adenylate cyclase interactions in rat reticulocytes.

1. Levels of G-proteins in liver and brain of lean and obese (ob/ob) mice.