Literature DB >> 25056763

Organocatalysed multicomponent synthesis of pyrazolidinones: Meldrum's acid approach.

Etienne Pair1, Christophe Berini, Romain Noël, Morgane Sanselme, Vincent Levacher, Jean-François Brière.   

Abstract

We discovered a novel organocatalysed multicomponent domino Knoevenagel-aza-Michael-cyclocondensation reaction leading to an unprecedented straightforward synthesis of 1,5-diazabicyclo[3.3.0]octane-2,6-diones. The specific capability of the (DHQ)2PHAL organocatalyst in this process was also highlighted to eventually furnish the corresponding bicyclopyrazolidinones with up to 96 : 4 er.

Entities:  

Year:  2014        PMID： 25056763     DOI： 10.1039/c4cc04852k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Alkaloid-Catalyzed Enantioselective [3 + 2] Cycloaddition of Ketenes and Azomethine Imines.

Authors:  Mukulesh Mondal; Kraig A Wheeler; Nessan J Kerrigan
Journal:  Org Lett       Date:  2016-08-08       Impact factor: 6.005

2.  Asymmetric Synthesis of Bicyclic Pyrazolidinones through Alkaloid-Catalyzed [3+2]-Cycloadditions of Ketenes and Azomethine Imines.

Authors:  Mukulesh Mondal; Shubhanjan Mitra; Dylan J Twardy; Manashi Panda; Kraig A Wheeler; Nessan J Kerrigan
Journal:  Chemistry       Date:  2022-03-14       Impact factor: 5.020

3.  Crystal structure of 5-[4-(di-ethyl-amino)-benzyl-idene]-2,2-dimethyl-1,3-dioxane-4,6-dione.

Authors:  Egija Stepina; Dmitrijs Stepanovs; Inese Mierina; Mara Jure
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-09-26
  3 in total

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