Cost-effectiveness of outpatient parenteral antibiotics: a review of the literature.

The results of studies completed on parenteral antibiotic therapy administered in an outpatient setting are reviewed. Although they varied in both size and sophistication, the studies all found that when patients and their families were carefully screened, outpatient therapy was a cost-effective, safe method of administering intravenous antibiotics. The methods used to compare the costs of inpatient and outpatient intravenous antibiotic therapy varied widely. Only direct costs were included in the early comparisons of inpatient and outpatient therapy, whereas the more recent studies included both direct and indirect costs and benefits. All studies found cost savings in the outpatient setting. Unfortunately, very few elderly patients were included because of a Medicare requirement that intravenous antibiotic therapy be administered or supervised by a physician. However, beginning in 1990, the Medicare Catastrophic Coverage Act of 1988 will cover intravenous drugs administered at home. Thus, it will be possible to study applicability of this therapy for the elderly population.