Jane J Rogathe1, Jim Todd2, Ewan Hunter3, Richard Walker4, Antony Ngugi5, Charles Newton6, Kathryn Burton7. 1. Kilimanjaro Christian Medical University College, Moshi, Tanzania. 2. Kilimanjaro Christian Medical University College, Moshi, Tanzania; National Institute for Medical Research, Mwanza, Tanzania. 3. Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Tropical Medicine, London, UK. 4. Northumbria Healthcare NHS Foundation Trust, North Tyneside General Hospital, North Shields, UK. 5. Centre for Geographical Medice (Coast), Kenya Medical Research Institute, Kilifi, Kenya. 6. Department of Paediatrics, Muhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania; Department of Psychiatry, University of Oxford, Oxford, UK. 7. Neurosciences Unit, Institute of Child Health, University College London, London, UK. Electronic address: kjburton@doctors.org.uk.
Abstract
AIM: This cross-sectional study examined whether growth parameters were associated with epilepsy in children living in a rural community in sub-Saharan Africa (SSA). MATERIALS AND METHODS: A cross-sectional study was performed in the Hai District Demographic Surveillance Site (HDSS), Tanzania in which 6-14 year old children with epilepsy (CWE) were identified. Age matched controls were randomly selected from the Hai census database for comparison. Anthropometric measurements were used to assess the nutritional status of the children and body mass index (BMI) calculated. Associations between social, demographic and nutritional factors and epilepsy were assessed using multivariable logistic regression. RESULTS: 112 CWE were identified and were compared with 113 controls. There was no significant difference in the BMI between cases and controls (T-test, p-value of 0.117). Amongst cases, there were no significant associations between BMI and motor difficulties, antiepileptic drug use, cognitive or behavioural problems, early-onset epilepsy or seizure frequency. In the whole group, BMI was significantly associated with socio-economic status (p=0.037) and age. DISCUSSION: There was no significant difference found between CWE and matched controls with respect to nutritional status. This suggests that there is no causal association between under nutrition and epilepsy in this community. Nutritional assessment is still important as part of the comprehensive care of CWE.
RCT Entities:
AIM: This cross-sectional study examined whether growth parameters were associated with epilepsy in children living in a rural community in sub-Saharan Africa (SSA). MATERIALS AND METHODS: A cross-sectional study was performed in the Hai District Demographic Surveillance Site (HDSS), Tanzania in which 6-14 year old children with epilepsy (CWE) were identified. Age matched controls were randomly selected from the Hai census database for comparison. Anthropometric measurements were used to assess the nutritional status of the children and body mass index (BMI) calculated. Associations between social, demographic and nutritional factors and epilepsy were assessed using multivariable logistic regression. RESULTS: 112 CWE were identified and were compared with 113 controls. There was no significant difference in the BMI between cases and controls (T-test, p-value of 0.117). Amongst cases, there were no significant associations between BMI and motor difficulties, antiepileptic drug use, cognitive or behavioural problems, early-onset epilepsy or seizure frequency. In the whole group, BMI was significantly associated with socio-economic status (p=0.037) and age. DISCUSSION: There was no significant difference found between CWE and matched controls with respect to nutritional status. This suggests that there is no causal association between under nutrition and epilepsy in this community. Nutritional assessment is still important as part of the comprehensive care of CWE.
Authors: Kathryn Burton; Jane Rogathe; Ewan Hunter; Matthew Burton; Mark Swai; Jim Todd; Brian Neville; Richard Walker; Charles Newton Journal: Dev Med Child Neurol Date: 2011-12 Impact factor: 5.449
Authors: Kathryn J Burton; Jane Rogathe; Roger Whittaker; Kshitij Mankad; Ewan Hunter; Matthew J Burton; Jim Todd; Brian G R Neville; Richard Walker; Charles R J C Newton Journal: Epilepsia Date: 2012-02-06 Impact factor: 5.864
Authors: Kathryn Burton; Jane Rogathe; Roger G Whittaker; Kshitij Mankad; Ewan Hunter; Matthew J Burton; Jim Todd; Brian G R Neville; Richard Walker; Charles R J C Newton Journal: Seizure Date: 2011-11-29 Impact factor: 3.184