Literature DB >> 25050174

Azapropellanes with anti-influenza a virus activity.

Eva Torres1, Rosana Leiva1, Sabrina Gazzarrini2, Matías Rey-Carrizo1, Marta Frigolé-Vivas1, Anna Moroni2, Lieve Naesens3, Santiago Vázquez1.   

Abstract

The synthesis of several [4,4,3], [4,3,3], and [3,3,3]azapropellanes is reported. Several of the novel amines displayed low-micromolar activities against an amantadine-resistant H1N1 strain, but they did not show activity against an amantadine-sensitive H3N2 strain. None of the tested compounds inhibit the influenza A/M2 proton channel function. Most of the compounds did not show cytotoxicity for MDCK cells.

Entities:  

Keywords:  Amantadine; M2 channel; hemagglutinin; influenza; propellane

Year:  2014        PMID： 25050174      PMCID： PMC4094260          DOI： 10.1021/ml500108s

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  26 in total

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