Literature DB >> 29767953

Pharmacological and Electrophysiological Characterization of Novel NMDA Receptor Antagonists.

Rosana Leiva1, Matthew B Phillips2, Andreea L Turcu1,3, Esther Gratacòs-Batlle3, Lara León-García4, Francesc X Sureda4, David Soto3, Jon W Johnson2, Santiago Vázquez1.   

Abstract

This work reports the synthesis and pharmacological and electrophysiological evaluation of new N-methyl-d-aspartic acid receptor (NMDAR) channel blocking antagonists featuring polycyclic scaffolds. Changes in the chemical structure modulate the potency and voltage dependence of inhibition. Two of the new antagonists display properties comparable to those of memantine, a clinically approved NMDAR antagonist.

Entities:  

Keywords:  Alzheimer’s disease; NMDA receptor; electrophysiology; glutamate; memantine; polycyclic amines

Mesh：

Substances：

Year:  2018        PMID： 29767953      PMCID： PMC6249113          DOI： 10.1021/acschemneuro.8b00154

Source DB:  PubMed          Journal:  ACS Chem Neurosci        ISSN： 1948-7193            Impact factor:   4.418


  55 in total

Review 1.  NMDA receptor subunits: diversity, development and disease.

Authors:  S Cull-Candy; S Brickley; M Farrant
Journal:  Curr Opin Neurobiol       Date:  2001-06       Impact factor: 6.627

Review 2.  The glutamate receptor ion channels.

Authors:  R Dingledine; K Borges; D Bowie; S F Traynelis
Journal:  Pharmacol Rev       Date:  1999-03       Impact factor: 25.468

Review 3.  NMDA receptors in nervous system diseases.

Authors:  Qiang Zhou; Morgan Sheng
Journal:  Neuropharmacology       Date:  2013-04-11       Impact factor: 5.250

Review 4.  N-methyl-D-aspartic acid receptor structure and function.

Authors:  C J McBain; M L Mayer
Journal:  Physiol Rev       Date:  1994-07       Impact factor: 37.312

Review 5.  Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists.

Authors:  Keith W Muir
Journal:  Curr Opin Pharmacol       Date:  2005-12-15       Impact factor: 5.547

Review 6.  Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

Authors:  Chrysanthy Ikonomidou; Lechoslaw Turski
Journal:  Lancet Neurol       Date:  2002-10       Impact factor: 44.182

Review 7.  Pathologically activated therapeutics for neuroprotection.

Authors:  Stuart A Lipton
Journal:  Nat Rev Neurosci       Date:  2007-10       Impact factor: 34.870

8.  Crystal structure of a heterotetrameric NMDA receptor ion channel.

Authors:  Erkan Karakas; Hiro Furukawa
Journal:  Science       Date:  2014-05-30       Impact factor: 47.728

9.  NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors.

Authors:  X Zhou; D Hollern; J Liao; E Andrechek; H Wang
Journal:  Cell Death Dis       Date:  2013-03-28       Impact factor: 8.469

10.  NMDA receptor structures reveal subunit arrangement and pore architecture.

Authors:  Chia-Hsueh Lee; Wei Lü; Jennifer Carlisle Michel; April Goehring; Juan Du; Xianqiang Song; Eric Gouaux
Journal:  Nature       Date:  2014-06-22       Impact factor: 49.962
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  5 in total

1.  Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.

Authors:  Andreea L Turcu; Júlia Companys-Alemany; Matthew B Phillips; Dhilon S Patel; Christian Griñán-Ferré; M Isabel Loza; José M Brea; Belén Pérez; David Soto; Francesc X Sureda; Maria G Kurnikova; Jon W Johnson; Mercè Pallàs; Santiago Vázquez
Journal:  Eur J Med Chem       Date:  2022-04-08       Impact factor: 7.088

2.  NMDA receptor antagonists reduce amyloid-β deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice.

Authors:  Júlia Companys-Alemany; Andreea L Turcu; Marion Schneider; Christa E Müller; Santiago Vázquez; Christian Griñán-Ferré; Mercè Pallàs
Journal:  Cell Mol Life Sci       Date:  2022-07-09       Impact factor: 9.207

3.  Inhibition of NMDA receptors through a membrane-to-channel path.

Authors:  Madeleine R Wilcox; Aparna Nigam; Nathan G Glasgow; Chamali Narangoda; Matthew B Phillips; Dhilon S Patel; Samaneh Mesbahi-Vasey; Andreea L Turcu; Santiago Vázquez; Maria G Kurnikova; Jon W Johnson
Journal:  Nat Commun       Date:  2022-07-15       Impact factor: 17.694

4.  Dual action of amitriptyline on NMDA receptors: enhancement of Ca-dependent desensitization and trapping channel block.

Authors:  Yulia D Stepanenko; Sergei I Boikov; Dmitry A Sibarov; Polina A Abushik; Nina P Vanchakova; Daria Belinskaia; Natalia N Shestakova; Sergei M Antonov
Journal:  Sci Rep       Date:  2019-12-19       Impact factor: 4.379

5.  A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice.

Authors:  Júlia Companys-Alemany; Andreea L Turcu; Aina Bellver-Sanchis; Maria I Loza; José M Brea; Anna M Canudas; Rosana Leiva; Santiago Vázquez; Mercè Pallàs; Christian Griñán-Ferré
Journal:  Pharmaceutics       Date:  2020-03-22       Impact factor: 6.321
  5 in total

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