Literature DB >> 2504707

Putative metal finger structure of the human immunodeficiency virus type 1 enhancer binding protein HIV-EP1.

T Maekawa1, H Sakura, T Sudo, S Ishii.   

Abstract

The region containing two copies of the sequence GGGACTTTCC in the human immunodeficiency virus type 1 (HIV-1) long terminal repeat, that is an NF-kappa B binding site, functions as an enhancer element for HIV transcriptional regulation. By a Southwestern method we have isolated a cDNA encoding the HIV-1 enhancer binding protein (HIV-EP1) from a human B-cell lambda gt11 library. DNase I footprinting analysis using the HIV-EP1 protein expressed in Escherichia coli showed that HIV-EP1 specifically bound to the HIV-1 enhancer. HIV-EP1 protein contains a domain with two tandem "zinc finger" sequences initially described in the Xenopus transcription factor IIIA. This represents the first demonstration of the structural feature of the protein that binds to the HIV-1 enhancer.

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Year:  1989        PMID： 2504707

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  24 in total

1.  Characterization of the mouse dynamin I gene promoter and identification of sequences that direct expression in neuronal cells.

Authors:  J Yoo; S S Lee; M J Jeong; K I Lee; B M Kwon; S H Kim; Y M Park; M Y Han
Journal:  Biochem J       Date:  2000-11-01       Impact factor: 3.857

2.  Conservation of mouse alpha A-crystallin promoter activity in chicken lens epithelial cells.

Authors:  D M Donovan; C M Sax; J F Klement; X Li; A B Chepelinsky; J Piatigorsky
Journal:  J Mol Evol       Date:  1992-10       Impact factor: 2.395

Review 3.  ZAS: C2H2 zinc finger proteins involved in growth and development.

Authors:  Lai-Chu Wu
Journal:  Gene Expr       Date:  2002

4.  DNA-binding properties of the E1A-associated 300-kilodalton protein.

Authors:  Y Rikitake; E Moran
Journal:  Mol Cell Biol       Date:  1992-06       Impact factor: 4.272

5.  Species-specific lens activation of the thymidine kinase promoter by a single copy of the mouse alpha A-CRYBP1 site and loss of tissue specificity by multimerization.

Authors:  C M Sax; J F Klement; J Piatigorsky
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

6.  ZAS3 accentuates transforming growth factor β signaling in epithelial cells.

Authors:  Adam J Yakovich; Bo Jiang; Carl E Allen; Jianguo Du; Lai-Chu Wu; John A Barnard
Journal:  Cell Signal       Date:  2010-08-21       Impact factor: 4.315

7.  Two upstream elements activate transcription of a major histocompatibility complex class I gene in vitro.

Authors:  P H Driggers; B A Elenbaas; J B An; I J Lee; K Ozato
Journal:  Nucleic Acids Res       Date:  1992-05-25       Impact factor: 16.971

8.  Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes.

Authors:  T Nakamura; D M Donovan; K Hamada; C M Sax; B Norman; J R Flanagan; K Ozato; H Westphal; J Piatigorsky
Journal:  Mol Cell Biol       Date:  1990-07       Impact factor: 4.272

9.  Compilation of vertebrate-encoded transcription factors.

Authors:  S Faisst; S Meyer
Journal:  Nucleic Acids Res       Date:  1992-01-11       Impact factor: 16.971

10.  A zinc finger transcription factor, alphaA-crystallin binding protein 1, is a negative regulator of the chondrocyte-specific enhancer of the alpha1(II) collagen gene.

Authors:  K Tanaka; Y Matsumoto; F Nakatani; Y Iwamoto; Y Yamada
Journal:  Mol Cell Biol       Date:  2000-06       Impact factor: 4.272
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