Literature DB >> 2247086

Species-specific lens activation of the thymidine kinase promoter by a single copy of the mouse alpha A-CRYBP1 site and loss of tissue specificity by multimerization.

C M Sax1, J F Klement, J Piatigorsky.   

Abstract

One copy of the mouse alpha A-crystallin gene alpha A-CRYBP1 site activated the thymidine kinase (tk) promoter in a mouse lens epithelial cell line but not in primary chicken lens cells; multiple copies further activated the tk promoter and extended expression to fibroblasts, B cells, and chicken lens cultures. The loss of lens specificity by multimerization may place selective constraints on the number of alpha A-CRYBP1 sites in the alpha A-crystallin promoter.

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Year:  1990        PMID： 2247086      PMCID： PMC362964          DOI： 10.1128/mcb.10.12.6813-6816.1990

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  29 in total

1.  Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes.

Authors:  T Nakamura; D M Donovan; K Hamada; C M Sax; B Norman; J R Flanagan; K Ozato; H Westphal; J Piatigorsky
Journal:  Mol Cell Biol       Date:  1990-07       Impact factor: 4.272

2.  A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes.

Authors:  A S Baldwin; K P LeClair; H Singh; P A Sharp
Journal:  Mol Cell Biol       Date:  1990-04       Impact factor: 4.272

3.  Synthesis of alpha-crystallin by a cell line derived from the lens of a transgenic animal.

Authors:  T Yamada; T Nakamura; H Westphal; P Russell
Journal:  Curr Eye Res       Date:  1990-01       Impact factor: 2.424

4.  Lens-specific expression of the chloramphenicol acetyltransferase gene promoted by 5' flanking sequences of the murine alpha A-crystallin gene in explanted chicken lens epithelia.

Authors:  A B Chepelinsky; C R King; P S Zelenka; J Piatigorsky
Journal:  Proc Natl Acad Sci U S A       Date:  1985-04       Impact factor: 11.205

5.  Cell-specific antigens and immunoglobulin synthesis of murine myeloma cells and their variants.

Authors:  R Hyman; P Ralph; S Sarkar
Journal:  J Natl Cancer Inst       Date:  1972-01       Impact factor: 13.506

6.  A new technique for the assay of infectivity of human adenovirus 5 DNA.

Authors:  F L Graham; A J van der Eb
Journal:  Virology       Date:  1973-04       Impact factor: 3.616

7.  The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

Authors:  C M Gorman; G T Merlino; M C Willingham; I Pastan; B H Howard
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

8.  Glucocorticoid responsiveness of the transcriptional enhancer of Moloney murine sarcoma virus.

Authors:  R Miksicek; A Heber; W Schmid; U Danesch; G Posseckert; M Beato; G Schütz
Journal:  Cell       Date:  1986-07-18       Impact factor: 41.582

9.  Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice.

Authors:  P A Overbeek; A B Chepelinsky; J S Khillan; J Piatigorsky; H Westphal
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

10.  Expression of a preproinsulin-beta-galactosidase gene fusion in mammalian cells.

Authors:  D A Nielsen; J Chou; A J MacKrell; M J Casadaban; D F Steiner
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205
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  6 in total

1.  Conservation of mouse alpha A-crystallin promoter activity in chicken lens epithelial cells.

Authors:  D M Donovan; C M Sax; J F Klement; X Li; A B Chepelinsky; J Piatigorsky
Journal:  J Mol Evol       Date:  1992-10       Impact factor: 2.395

2.  Compilation of vertebrate-encoded transcription factors.

Authors:  S Faisst; S Meyer
Journal:  Nucleic Acids Res       Date:  1992-01-11       Impact factor: 16.971

3.  The alpha A-crystallin gene: conserved features of the 5'-flanking regions in human, mouse, and chicken.

Authors:  C J Jaworski; A B Chepelinsky; J Piatigorsky
Journal:  J Mol Evol       Date:  1991-12       Impact factor: 2.395

4.  Transcriptional regulation of the mouse alpha A-crystallin gene: activation dependent on a cyclic AMP-responsive element (DE1/CRE) and a Pax-6-binding site.

Authors:  A Cvekl; F Kashanchi; C M Sax; J N Brady; J Piatigorsky
Journal:  Mol Cell Biol       Date:  1995-02       Impact factor: 4.272

5.  Functional redundancy of the DE-1 and alpha A-CRYBP1 regulatory sites of the mouse alpha A-crystallin promoter.

Authors:  C M Sax; J G Ilagan; J Piatigorsky
Journal:  Nucleic Acids Res       Date:  1993-06-11       Impact factor: 16.971

6.  Lens-specific activity of the mouse alpha A-crystallin promoter in the absence of a TATA box: functional and protein binding analysis of the mouse alpha A-crystallin PE1 region.

Authors:  C M Sax; A Cvekl; M Kantorow; R Gopal-Srivastava; J G Ilagan; N P Ambulos; J Piatigorsky
Journal:  Nucleic Acids Res       Date:  1995-02-11       Impact factor: 16.971
  6 in total

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