Eero Lauhkonen1, Petri Koponen1, Kirsi Nuolivirta2, Marita Paassilta3, Jyri Toikka4,5, Antti Saari6, Matti Korppi1. 1. Tampere Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland. 2. Seinäjoki Central Hospital, Seinäjoki, Finland. 3. Allergy Centre, Tampere University Hospital, Tampere, Finland. 4. Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland. 5. Department of Clinical Physiology, Turku University Hospital, Turku, Finland. 6. Kuopio University Hospital, Kuopio, Finland.
Abstract
BACKGROUND AND AIMS: Obesity has been linked with asthma symptoms, need for asthma treatment and reduced lung function but not with increased bronchial reactivity in children. The aim of this study was to evaluate the association between previous or current weight status and current lung function and bronchial reactivity to exercise at early school age. METHODS: Ninety-nine children hospitalized for bronchiolitis at the age of less than 6 months were studied with impulse oscillometry (IOS) at the mean age of 6.3 years. Data on birth weight and weight gain in infancy before hospitalization were collected during hospitalization. Current weight and height data were transformed into age- and sex-specific height-related body mass index z scores (zBMI) using the Finnish national population-based weight and height data as reference. RESULTS: Some significant though only low or modest correlations were found between current zBMI and baseline, post-exercise and post-bronchodilator IOS values in adjusted linear regression analysis. Seven obese children by zBMI had higher post-bronchodilator airway impedance (Zrs) and resistance (Rrs) at 5 Hz and lower post-bronchodilator frequency dependency of resistance (dRrs/df) than normal weight children. There were no significant differences in responses to exercise or to bronchodilators between currently obese or overweight children and normal weight children. Birth weight less than 3,000 g was associated with larger exercise-induced changes in Zrs and Rrs at 5 Hz, and in reactance (Xrs) at 5 Hz, than those with birth weight more than 3,000 g. CONCLUSIONS: Preliminary evidence was found that obesity may be associated with airway obstruction, but not with bronchial hyper-reactivity.
BACKGROUND AND AIMS: Obesity has been linked with asthma symptoms, need for asthma treatment and reduced lung function but not with increased bronchial reactivity in children. The aim of this study was to evaluate the association between previous or current weight status and current lung function and bronchial reactivity to exercise at early school age. METHODS: Ninety-nine children hospitalized for bronchiolitis at the age of less than 6 months were studied with impulse oscillometry (IOS) at the mean age of 6.3 years. Data on birth weight and weight gain in infancy before hospitalization were collected during hospitalization. Current weight and height data were transformed into age- and sex-specific height-related body mass index z scores (zBMI) using the Finnish national population-based weight and height data as reference. RESULTS: Some significant though only low or modest correlations were found between current zBMI and baseline, post-exercise and post-bronchodilator IOS values in adjusted linear regression analysis. Seven obesechildren by zBMI had higher post-bronchodilator airway impedance (Zrs) and resistance (Rrs) at 5 Hz and lower post-bronchodilator frequency dependency of resistance (dRrs/df) than normal weight children. There were no significant differences in responses to exercise or to bronchodilators between currently obese or overweight children and normal weight children. Birth weight less than 3,000 g was associated with larger exercise-induced changes in Zrs and Rrs at 5 Hz, and in reactance (Xrs) at 5 Hz, than those with birth weight more than 3,000 g. CONCLUSIONS: Preliminary evidence was found that obesity may be associated with airway obstruction, but not with bronchial hyper-reactivity.
Authors: Eero Lauhkonen; Petri Koponen; Johanna Teräsjärvi; Kirsi Gröndahl-Yli-Hannuksela; Juho Vuononvirta; Kirsi Nuolivirta; Jyri O Toikka; Merja Helminen; Qiushui He; Matti Korppi Journal: PLoS One Date: 2015-10-16 Impact factor: 3.240
Authors: Marcus H Jones; Cristian Roncada; Morgana Thais Carollo Fernandes; João Paulo Heinzmann-Filho; Edgar Enrique Sarria Icaza; Rita Mattiello; Paulo Marcio C Pitrez; Leonardo A Pinto; Renato T Stein Journal: Front Pediatr Date: 2017-12-18 Impact factor: 3.418