Literature DB >> 25043138

Discrimination between olfactory receptor agonists and non-agonists.

Jérémie Topin1, Claire A de March, Landry Charlier, Catherine Ronin, Serge Antonczak, Jérôme Golebiowski.   

Abstract

A joint approach combining free-energy calculations and calcium-imaging assays on the broadly tuned human 1G1 olfactory receptor is reported. The free energy of binding of ten odorants was computed by means of molecular-dynamics simulations. This state function allows separating the experimentally determined eight agonists from the two non-agonists. This study constitutes a proof-of-principle for the computational deorphanization of olfactory receptors.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  calcium imaging; free energy; molecular modeling; odorants; receptors

Mesh：

Substances：

Year:  2014        PMID： 25043138     DOI： 10.1002/chem.201402486

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  12 in total

Review 1.  Structure-Function Relationships of Olfactory and Taste Receptors.

Authors:  Maik Behrens; Loïc Briand; Claire A de March; Hiroaki Matsunami; Atsuko Yamashita; Wolfgang Meyerhof; Simone Weyand
Journal:  Chem Senses       Date:  2018-02-02       Impact factor: 3.160

2.  Odorant Receptor 7D4 Activation Dynamics.

Authors:  Claire A de March; Jérémie Topin; Elise Bruguera; Gleb Novikov; Kentaro Ikegami; Hiroaki Matsunami; Jérôme Golebiowski
Journal:  Angew Chem Int Ed Engl       Date:  2018-03-24       Impact factor: 15.336

3.  Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptors.

Authors:  Claire A de March; Yiqun Yu; Mengjue J Ni; Kaylin A Adipietro; Hiroaki Matsunami; Minghong Ma; Jérôme Golebiowski
Journal:  J Am Chem Soc       Date:  2015-06-29       Impact factor: 15.419

4.  Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds.

Authors:  Lucky Ahmed; Yuetian Zhang; Eric Block; Michael Buehl; Michael J Corr; Rodrigo A Cormanich; Sivaji Gundala; Hiroaki Matsunami; David O'Hagan; Mehmet Ozbil; Yi Pan; Sivakumar Sekharan; Nicholas Ten; Mingan Wang; Mingyan Yang; Qingzhi Zhang; Ruina Zhang; Victor S Batista; Hanyi Zhuang
Journal:  Proc Natl Acad Sci U S A       Date:  2018-04-09       Impact factor: 11.205

5.  Mammalian class I odorant receptors exhibit a conserved vestibular-binding pocket.

Authors:  Caroline Bushdid; Claire A de March; Jérémie Topin; Matthew Do; Hiroaki Matsunami; Jérôme Golebiowski
Journal:  Cell Mol Life Sci       Date:  2019-01-01       Impact factor: 9.261

6.  Dynamical Binding Modes Determine Agonistic and Antagonistic Ligand Effects in the Prostate-Specific G-Protein Coupled Receptor (PSGR).

Authors:  Steffen Wolf; Nikolina Jovancevic; Lian Gelis; Sebastian Pietsch; Hanns Hatt; Klaus Gerwert
Journal:  Sci Rep       Date:  2017-11-22       Impact factor: 4.379

7.  Computational Approaches for Decoding Select Odorant-Olfactory Receptor Interactions Using Mini-Virtual Screening.

Authors:  K Harini; Ramanathan Sowdhamini
Journal:  PLoS One       Date:  2015-07-29       Impact factor: 3.240

8.  Evidence for a shape-based recognition of odorants in vivo in the human nose from an analysis of the molecular mechanism of lily-of-the-valley odorants detection in the Lilial and Bourgeonal family using the C/Si/Ge/Sn switch strategy.

Authors:  Steffen Wolf; Lian Gelis; Steffen Dörrich; Hanns Hatt; Philip Kraft
Journal:  PLoS One       Date:  2017-08-01       Impact factor: 3.240

9.  Shining Light on Molecular Mechanism for Odor-selectivity of CNT-immobilized Olfactory Receptor.

Authors:  Liyun Zhang; Yuan Yuan; Tian Ren; Yanzhi Guo; Chuan Li; Xuemei Pu
Journal:  Sci Rep       Date:  2018-05-18       Impact factor: 4.379

10.  Bitter Taste and Olfactory Receptors: Beyond Chemical Sensing in the Tongue and the Nose.

Authors:  Mercedes Alfonso-Prieto
Journal:  J Membr Biol       Date:  2021-06-25       Impact factor: 1.843
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.