BACKGROUND AND OBJECTIVES: Vitamin D has been studied primarily for its involvement in calcium and phosphate absorption and bone metabolism. The active form of vitamin D-1,25(OH)2 D-has also been investigated for its immune modulatory properties. We explored associations between serum levels of 25(OH)D and 1,25(OH)2 D and periodontal health. SUBJECTS AND METHODS: This case-control study included 55 subjects with chronic periodontitis (cases) and 30 periodontally healthy subjects (controls). Their serum levels of 25(OH)D, 1,25(OH)2 D, ultrasensitive C-reactive protein and high-density lipoprotein cholesterol were determined. Associations between vitamin D and periodontal health status were studied using logistic regression analysis. RESULTS: A statistically significant association was found between serum 1,25(OH)2 D level and periodontal health status; in that subjects with a low 1,25(OH)2 D were more likely to belong to the periodontitis group (OR = 0.97, 95% CI = 0.95-1.00). There was practically no association between 25(OH)D level and periodontal health status. CONCLUSION: In this case-control study low serum 1,25(OH)2 D level appeared to be associated with periodontitis, which was in line with the previously reported associations between serum 1,25(OH)2 D levels and other inflammatory diseases. Whether this association is causal in nature, remains to be confirmed in future studies.
BACKGROUND AND OBJECTIVES:Vitamin D has been studied primarily for its involvement in calcium and phosphate absorption and bone metabolism. The active form of vitamin D-1,25(OH)2 D-has also been investigated for its immune modulatory properties. We explored associations between serum levels of 25(OH)D and 1,25(OH)2 D and periodontal health. SUBJECTS AND METHODS: This case-control study included 55 subjects with chronic periodontitis (cases) and 30 periodontally healthy subjects (controls). Their serum levels of 25(OH)D, 1,25(OH)2 D, ultrasensitive C-reactive protein and high-density lipoprotein cholesterol were determined. Associations between vitamin D and periodontal health status were studied using logistic regression analysis. RESULTS: A statistically significant association was found between serum 1,25(OH)2 D level and periodontal health status; in that subjects with a low 1,25(OH)2 D were more likely to belong to the periodontitis group (OR = 0.97, 95% CI = 0.95-1.00). There was practically no association between 25(OH)D level and periodontal health status. CONCLUSION: In this case-control study low serum 1,25(OH)2 D level appeared to be associated with periodontitis, which was in line with the previously reported associations between serum 1,25(OH)2 D levels and other inflammatory diseases. Whether this association is causal in nature, remains to be confirmed in future studies.
Authors: Markus Laky; Kristina Bertl; Hady Haririan; Oleh Andrukhov; Rudolf Seemann; Ivo Volf; Alice Assinger; Reinhard Gruber; Andreas Moritz; Xiaohui Rausch-Fan Journal: Clin Oral Investig Date: 2016-09-29 Impact factor: 3.573
Authors: Mohamed M Meghil; Lance Hutchens; Anas Raed; Neha A Multani; Mythilypriya Rajendran; Haidong Zhu; Stephen Looney; Mahmoud Elashiry; Roger M Arce; Mark E Peacock; Yanbin Dong; Christopher W Cutler Journal: Oral Dis Date: 2019-04-21 Impact factor: 3.511
Authors: Lorenzo P Menzel; Willam Ruddick; Mobaswar H Chowdhury; David C Brice; Ryan Clance; Emily Porcelli; Lisa K Ryan; Jungnam Lee; Özlem Yilmaz; Keith L Kirkwood; Laura McMahon; Amy Tran; Gill Diamond Journal: J Periodontal Res Date: 2019-02-25 Impact factor: 3.946
Authors: Abdullah Ali H Alzahrani; Raed A Alharbi; Mohammed Sarhan A Alzahrani; Mohammed A Sindi; Ghalia Shamlan; Faisal A Alzahrani; Mohammad A Albanghali; Abdulmajeed Abdulghani A Sindi Journal: Saudi J Biol Sci Date: 2021-04-20 Impact factor: 4.052