OBJECTIVE: Explore interrelationships between suicide attempt history (Objective 1) or suicide attempt severity (Objective 2) with prefrontal cortex gray matter (PFCGM ) volume and illness-course in patients with bipolar disorder (BD). METHOD: Ninety-three women with BD-I or -II diagnosis (51 with and 42 without suicide attempt history) underwent structural MRI and filled out questionnaires. Measured were GM volumes of 11 PFC regions, BD illness-course, and attempt history and severity. Effects were examined with repeated measures GLM or logit analyses. RESULTS: Objective 1: Attempt history was associated with increased trait impulsivity and aggression, and higher prevalence of BD-I, past drug use disorder, and past psychiatric hospitalization. PFCGM volume was lower in patients with than without attempt history in those with past psychiatric hospitalization. PFCGM volume was higher in patients with than without attempt history in those without hospitalization. Higher trait aggression predicted attempt history. Objective 2: Increased frontal pole volume and younger age at first hospitalization predicted many suicide attempts. CONCLUSION: Attempt history in patients with BD related to PFCGM volume reduction or increase. Volume modulation by psychiatric hospitalization could reflect effects of illness-course or care. Attempt severity was not related to volume reduction. Research on suicidality-brain relationships should include illness-course and attempt severity measures.
OBJECTIVE: Explore interrelationships between suicide attempt history (Objective 1) or suicide attempt severity (Objective 2) with prefrontal cortex gray matter (PFCGM ) volume and illness-course in patients with bipolar disorder (BD). METHOD: Ninety-three women with BD-I or -II diagnosis (51 with and 42 without suicide attempt history) underwent structural MRI and filled out questionnaires. Measured were GM volumes of 11 PFC regions, BD illness-course, and attempt history and severity. Effects were examined with repeated measures GLM or logit analyses. RESULTS: Objective 1: Attempt history was associated with increased trait impulsivity and aggression, and higher prevalence of BD-I, past drug use disorder, and past psychiatric hospitalization. PFCGM volume was lower in patients with than without attempt history in those with past psychiatric hospitalization. PFCGM volume was higher in patients with than without attempt history in those without hospitalization. Higher trait aggression predicted attempt history. Objective 2: Increased frontal pole volume and younger age at first hospitalization predicted many suicide attempts. CONCLUSION: Attempt history in patients with BD related to PFCGM volume reduction or increase. Volume modulation by psychiatric hospitalization could reflect effects of illness-course or care. Attempt severity was not related to volume reduction. Research on suicidality-brain relationships should include illness-course and attempt severity measures.
Authors: Mina M Rizk; Harry Rubin-Falcone; Xuejing Lin; John G Keilp; Jeffrey M Miller; Matthew S Milak; M Elizabeth Sublette; Maria A Oquendo; R Todd Ogden; Nashaat A Abdelfadeel; Mohamed A Abdelhameed; J John Mann Journal: Psychiatry Res Neuroimaging Date: 2018-11-14 Impact factor: 2.376
Authors: Louise Öhlund; Michael Ott; Robert Lundqvist; Mikael Sandlund; Ellinor Salander Renberg; Ursula Werneke Journal: Ther Adv Psychopharmacol Date: 2020-08-06
Authors: Carmen Domínguez-Baleón; Luis F Gutiérrez-Mondragón; Adrián I Campos-González; Miguel E Rentería Journal: Front Psychiatry Date: 2018-10-16 Impact factor: 4.157
Authors: Adrian I Campos; Paul M Thompson; Dick J Veltman; Elena Pozzi; Laura S van Veltzen; Neda Jahanshad; Mark J Adams; Bernhard T Baune; Klaus Berger; Katharina Brosch; Robin Bülow; Colm G Connolly; Udo Dannlowski; Christopher G Davey; Greig I de Zubicaray; Danai Dima; Tracy Erwin-Grabner; Jennifer W Evans; Cynthia H Y Fu; Ian H Gotlib; Roberto Goya-Maldonado; Hans J Grabe; Dominik Grotegerd; Matthew A Harris; Ben J Harrison; Sean N Hatton; Marco Hermesdorf; Ian B Hickie; Tiffany C Ho; Tilo Kircher; Axel Krug; Jim Lagopoulos; Hannah Lemke; Katie McMahon; Frank P MacMaster; Nicholas G Martin; Andrew M McIntosh; Sarah E Medland; Susanne Meinert; Tina Meller; Igor Nenadic; Nils Opel; Ronny Redlich; Liesbeth Reneman; Jonathan Repple; Matthew D Sacchet; Simon Schmitt; Anouk Schrantee; Kang Sim; Aditya Singh; Frederike Stein; Lachlan T Strike; Nic J A van der Wee; Steven J A van der Werff; Henry Völzke; Lena Waltemate; Heather C Whalley; Katharina Wittfeld; Margaret J Wright; Tony T Yang; Carlos A Zarate; Lianne Schmaal; Miguel E Rentería Journal: Biol Psychiatry Date: 2021-03-21 Impact factor: 12.810