| Literature DB >> 25036774 |
Abstract
The tandem bromodomains (BD1 and BD2) of the BET family proteins BRD2, BRD3, BRD4, and BRDT are structurally conserved but not functionally equivalent. In this issue of Chemistry & Biology, Gacias and colleagues report that a BD1-specific chemical inhibitor, Olinone, enhances oligodendrocyte differentiation, contrasting the reverse process triggered by broad BD1/BD2-targeting inhibitors, highlighting distinct roles of BD1 and BD2 in cell fate decision.Entities:
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Year: 2014 PMID： 25036774 PMCID： PMC4137397 DOI： 10.1016/j.chembiol.2014.07.003
Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521