Hack-Lyoung Kim1, Ju-Myung Lee1, Jae-Bin Seo1, Woo-Young Chung1, Sang-Hyun Kim1, Joo-Hee Zo1, Myung-A Kim2. 1. Division of Cardiology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea. 2. Division of Cardiology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: kma@brm.co.kr.
Abstract
OBJECTIVES: The influence of gender-dependent metabolic risk factors on arterial stiffness has not been fully determined. This study was performed to investigate the relationship between components of metabolic syndrome and brachial-ankle pulse wave velocity (baPWV) according to gender. METHODS: A total of 537 subjects (54.4±7.5 years and 70.6% men) who underwent baPWV measurement during routine check-ups were analyzed. RESULTS: BaPWV was 1363±229cm/s in men and 1387±269cm/s in women (p=0.313). The prevalence of metabolic syndrome was not different according to gender (23% in men versus 27% in women, p=0.335). In multiple linear regression analyses, after adjustment for age, baPWV was significantly associated with systolic and diastolic blood pressures, fasting glucose, and triglyceride in both genders. Waist circumference was associated with baPWV in women but not in men. High-density lipoprotein levels were not associated with baPWV in either gender. Subjects with metabolic syndrome had a higher baPWV than those without metabolic syndrome for women aged <55 years, but not for all men and women aged ≥55 years. As the number of the components of metabolic syndrome increased, baPWV increased proportionally in both genders. However, this correlation was more strong in women than that in men (β=0.408 versus β=0.146 after adjustment for age). CONCLUSION: In middle-aged Koreans, women showed stronger associations between each component of metabolic syndrome and baPWV than men. The association of each component of metabolic syndrome to arterial stiffness may differ between men and women.
OBJECTIVES: The influence of gender-dependent metabolic risk factors on arterial stiffness has not been fully determined. This study was performed to investigate the relationship between components of metabolic syndrome and brachial-ankle pulse wave velocity (baPWV) according to gender. METHODS: A total of 537 subjects (54.4±7.5 years and 70.6% men) who underwent baPWV measurement during routine check-ups were analyzed. RESULTS:BaPWV was 1363±229cm/s in men and 1387±269cm/s in women (p=0.313). The prevalence of metabolic syndrome was not different according to gender (23% in men versus 27% in women, p=0.335). In multiple linear regression analyses, after adjustment for age, baPWV was significantly associated with systolic and diastolic blood pressures, fasting glucose, and triglyceride in both genders. Waist circumference was associated with baPWV in women but not in men. High-density lipoprotein levels were not associated with baPWV in either gender. Subjects with metabolic syndrome had a higher baPWV than those without metabolic syndrome for women aged <55 years, but not for all men and women aged ≥55 years. As the number of the components of metabolic syndrome increased, baPWV increased proportionally in both genders. However, this correlation was more strong in women than that in men (β=0.408 versus β=0.146 after adjustment for age). CONCLUSION: In middle-aged Koreans, women showed stronger associations between each component of metabolic syndrome and baPWV than men. The association of each component of metabolic syndrome to arterial stiffness may differ between men and women.
Authors: Jaume Padilla; Makenzie L Woodford; Guido Lastra-Gonzalez; Vanesa Martinez-Diaz; Shumpei Fujie; Yan Yang; Alexandre M C Lising; Francisco I Ramirez-Perez; Annayya R Aroor; Mariana Morales-Quinones; Thaysa Ghiarone; Adam Whaley-Connell; Luis A Martinez-Lemus; Michael A Hill; Camila Manrique-Acevedo Journal: Endocrinology Date: 2019-12-01 Impact factor: 4.736
Authors: Leticia Gomez-Sanchez; Luis Garcia-Ortiz; M Carmen Patino-Alonso; Jose I Recio-Rodriguez; Rigo Fernando; Ruth Marti; Cristina Agudo-Conde; Emiliano Rodriguez-Sanchez; Jose A Maderuelo-Fernandez; Rafel Ramos; Manuel A Gomez-Marcos Journal: Cardiovasc Diabetol Date: 2016-10-24 Impact factor: 9.951