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Literature DB >> 25031750

Decreased expression of miR-204 is associated with poor prognosis in patients with breast cancer.

Weidong Li¹, Xuejun Jin¹, Qianbing Zhang², Gong Zhang³, Xubin Deng¹, Lei Ma¹.

Abstract

The identification of biomarkers in breast cancer diagnosis and therapy is important in achieving early cancer diagnosis and improving patient outcomes. The aim of this study was to examine clinical significance of miR-204 expression in tissues from breast cancer patients. The relationship between miR-204 expression and clinicopathological characteristics was investigated. MiR-204 expression was significantly associated with TNM stage and metastasis. Patients with low miR-204 expression had poorer overall survival time and disease free survival time than those with high miR-204 expression. Furthermore, miR-204 expression was correlated with chemotherapeutic resistance of breast cancer patients. In conclusion, the miR-204 may be a potential diagnostic and prognostic biomarker of breast cancer.

Entities: Disease Gene Species

Keywords: MiR-204; breast cancer; prognosis

Mesh：

Substances：

Year: 2014 PMID： 25031750 PMCID： PMC4097245

Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625

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