Chul Kim1, Hee Eun Choi2, Heejin Jung1, Seong Hoon Kang1, Jeong Hoon Kim3, Young Sup Byun3. 1. Department of Rehabilitation Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea. 2. Department of Rehabilitation Medicine, Inje University Haeundae Paik Hospital, Busan, Korea. 3. Division of Cardiology, Departments of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea.
Abstract
OBJECTIVE: To confirm the improvement in arterial endothelial function by aerobic exercise training, flow-mediated dilation (FMD) was tested by ultrasonography. METHODS: Patients who received percutaneous coronary intervention due to acute coronary syndrome were included. The patients who participated in cardiac rehabilitation (CR) program were categorized as the CR group, and others who did not participate as the control. Both groups underwent initial graded exercise test (GXT) and FMD testing. Subsequently, the CR group performed aerobic exercise training sessions. Patients in control only received advice regarding the exercise methods. After six weeks, both groups received follow-up GXT and FMD testing. RESULTS: There were 16 patients in each group. There were no significant differences in the general characteristics between the groups. The VO2peak was 28.6±4.7 mL/kg/min in the CR group and 31.5±7.4 mL/kg/min in the control at first GXT, and was 31.1±5.1 ml/kg/min in the CR group and 31.4±6.0 ml/kg/min in the control at the follow-up GXT in six weeks. There was a statistically significant improvement in VO2peak only for CR group patients. FMD value was 7.59%±1.26% in the CR group, 7.36%±1.48% in the control at first and 9.46%±1.82% in the CR group, and 8.31%±2.04% in the control after six weeks. There was a statistically significant improvement in FMD value in the CR group. CONCLUSION: According to the results of GXT and FMD testing, six-week exercise-based CR program improved VO2peak and endothelial functions significantly. Thus, exercise-based CR program is necessary in patients with coronary artery disease.
RCT Entities:
OBJECTIVE: To confirm the improvement in arterial endothelial function by aerobic exercise training, flow-mediated dilation (FMD) was tested by ultrasonography. METHODS:Patients who received percutaneous coronary intervention due to acute coronary syndrome were included. The patients who participated in cardiac rehabilitation (CR) program were categorized as the CR group, and others who did not participate as the control. Both groups underwent initial graded exercise test (GXT) and FMD testing. Subsequently, the CR group performed aerobic exercise training sessions. Patients in control only received advice regarding the exercise methods. After six weeks, both groups received follow-up GXT and FMD testing. RESULTS: There were 16 patients in each group. There were no significant differences in the general characteristics between the groups. The VO2peak was 28.6±4.7 mL/kg/min in the CR group and 31.5±7.4 mL/kg/min in the control at first GXT, and was 31.1±5.1 ml/kg/min in the CR group and 31.4±6.0 ml/kg/min in the control at the follow-up GXT in six weeks. There was a statistically significant improvement in VO2peak only for CR group patients. FMD value was 7.59%±1.26% in the CR group, 7.36%±1.48% in the control at first and 9.46%±1.82% in the CR group, and 8.31%±2.04% in the control after six weeks. There was a statistically significant improvement in FMD value in the CR group. CONCLUSION: According to the results of GXT and FMD testing, six-week exercise-based CR program improved VO2peak and endothelial functions significantly. Thus, exercise-based CR program is necessary in patients with coronary artery disease.
Authors: G T O'Connor; J E Buring; S Yusuf; S Z Goldhaber; E M Olmstead; R S Paffenbarger; C H Hennekens Journal: Circulation Date: 1989-08 Impact factor: 29.690
Authors: T J Anderson; M D Gerhard; I T Meredith; F Charbonneau; D Delagrange; M A Creager; A P Selwyn; P Ganz Journal: Am J Cardiol Date: 1995-02-23 Impact factor: 2.778
Authors: Véronique A Cornelissen; Steven Onkelinx; Kaatje Goetschalckx; Tom Thomaes; Stefan Janssens; Robert Fagard; Peter Verhamme; Luc Vanhees Journal: Eur J Prev Cardiol Date: 2012-09-07 Impact factor: 7.804
Authors: R Hambrecht; V Adams; S Erbs; A Linke; N Kränkel; Y Shu; Y Baither; S Gielen; H Thiele; J F Gummert; F W Mohr; G Schuler Journal: Circulation Date: 2003-06-16 Impact factor: 29.690
Authors: Shigeki Shibata; Naoki Fujimoto; Jeffrey L Hastings; Graeme Carrick-Ranson; Paul S Bhella; Christopher M Hearon; Benjamin D Levine Journal: J Physiol Date: 2018-05-30 Impact factor: 5.182
Authors: Rian Q Landers-Ramos; Kelsey J Corrigan; Lisa M Guth; Christine N Altom; Espen E Spangenburg; Steven J Prior; James M Hagberg Journal: Appl Physiol Nutr Metab Date: 2016-03-28 Impact factor: 2.665
Authors: Xiaohui Mou; Hongbo Zhang; Hua Qiu; Wentai Zhang; Ying Wang; Kaiqin Xiong; Nan Huang; Hélder A Santos; Zhilu Yang Journal: Research (Wash D C) Date: 2022-04-14
Authors: Rogerio N Soares; Juan M Murias; Flavia Saccone; Leopoldo Puga; Gustavo Moreno; Miguel Resnik; Gabriela F De Roia Journal: Physiol Rep Date: 2019-06