Literature DB >> 25023949

Extra sensory perception: the role of Gpr receptors in the kidney.

Jennifer L Pluznick1.   

Abstract

PURPOSE OF REVIEW: This review will summarize recent literature highlighting the roles of sensory Gpr receptors and their roles in renal function. RECENT
FINDINGS: Chemoreceptors play important roles in renal physiology wherein they modulate renal function in response to ligands from a variety of sources.
SUMMARY: As specialized chemical detectors, chemoreceptors in the kidney monitor the level of a variety of chemical ligands in the body and adjust renal function accordingly. In addition to olfactory receptors and taste receptors, G-protein coupled receptors of the orphan Gpr family are now being found to play a 'sensory' role in renal physiology. Identifying the physiological roles of these receptors and elucidating the cell biology underlying these signaling pathways can give us novel insights into renal function.

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Year:  2014        PMID： 25023949      PMCID： PMC4219497          DOI： 10.1097/MNH.0000000000000048

Source DB:  PubMed          Journal:  Curr Opin Nephrol Hypertens        ISSN： 1062-4821            Impact factor:   2.894


  62 in total

1.  R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.

Authors:  Kendra S Carmon; Xing Gong; Qiushi Lin; Anthony Thomas; Qingyun Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-21       Impact factor: 11.205

2.  Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3.

Authors:  Yasuaki Mohri; Kazunori Oyama; Atsushi Akamatsu; Shigeki Kato; Katsuhiko Nishimori
Journal:  Dev Dyn       Date:  2011-04-26       Impact factor: 3.780

3.  Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.

Authors:  Wim de Lau; Nick Barker; Teck Y Low; Bon-Kyoung Koo; Vivian S W Li; Hans Teunissen; Pekka Kujala; Andrea Haegebarth; Peter J Peters; Marc van de Wetering; Daniel E Stange; Johan E van Es; Daniele Guardavaccaro; Richard B M Schasfoort; Yasuaki Mohri; Katsuhiko Nishimori; Shabaz Mohammed; Albert J R Heck; Hans Clevers
Journal:  Nature       Date:  2011-07-04       Impact factor: 49.962

4.  GPR48 increases mineralocorticoid receptor gene expression.

Authors:  Jiqiu Wang; Xiaoying Li; Yingying Ke; Yan Lu; Feng Wang; Nengguang Fan; Haiyan Sun; Huijie Zhang; Ruixin Liu; Jun Yang; Lei Ye; Mingyao Liu; Guang Ning
Journal:  J Am Soc Nephrol       Date:  2011-12-01       Impact factor: 10.121

5.  LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

Authors:  Andrei Glinka; Christine Dolde; Nadine Kirsch; Ya-Lin Huang; Olga Kazanskaya; Dierk Ingelfinger; Michael Boutros; Cristina-Maria Cruciat; Christof Niehrs
Journal:  EMBO Rep       Date:  2011-09-30       Impact factor: 8.807

Review 6.  G-protein-coupled receptors as fat sensors.

Authors:  Marco A R Vinolo; Sandro M Hirabara; Rui Curi
Journal:  Curr Opin Clin Nutr Metab Care       Date:  2012-03       Impact factor: 4.294

Review 7.  The role of G-protein-coupled receptors in mediating the effect of fatty acids on inflammation and insulin sensitivity.

Authors:  Da Young Oh; William S Lagakos
Journal:  Curr Opin Clin Nutr Metab Care       Date:  2011-07       Impact factor: 4.294

8.  Unraveling the mechanisms underlying the rapid vascular effects of steroids: sorting out the receptors and the pathways.

Authors:  Ross D Feldman; Robert Gros
Journal:  Br J Pharmacol       Date:  2011-07       Impact factor: 8.739

9.  17β-Estradiol induces nongenomic effects in renal intercalated cells through G protein-coupled estrogen receptor 1.

Authors:  Marlene Vind Hofmeister; Helle Hasager Damkier; Birgitte Mønster Christensen; Björn Olde; L M Fredrik Leeb-Lundberg; Robert A Fenton; Helle A Praetorius; Jeppe Praetorius
Journal:  Am J Physiol Renal Physiol       Date:  2011-10-12

10.  T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1.

Authors:  Robert F Margolskee; Jane Dyer; Zaza Kokrashvili; Kieron S H Salmon; Erwin Ilegems; Kristian Daly; Emeline L Maillet; Yuzo Ninomiya; Bedrich Mosinger; Soraya P Shirazi-Beechey
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-27       Impact factor: 11.205
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  5 in total

1.  Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1.

Authors:  Harshal Waghulde; Xi Cheng; Sarah Galla; Blair Mell; Jingwei Cai; Shondra M Pruett-Miller; Guillermo Vazquez; Andrew Patterson; Matam Vijay Kumar; Bina Joe
Journal:  Hypertension       Date:  2018-11       Impact factor: 10.190

2.  Prebiotics, Probiotics, and Acetate Supplementation Prevent Hypertension in a Model of Obstructive Sleep Apnea.

Authors:  Bhanu P Ganesh; James W Nelson; Joshua R Eskew; Arunkumar Ganesan; Nadim J Ajami; Joseph F Petrosino; Robert M Bryan; David J Durgan
Journal:  Hypertension       Date:  2018-11       Impact factor: 10.190

3.  Identification and characterization of novel renal sensory receptors.

Authors:  Premraj Rajkumar; William H Aisenberg; Omar W Acres; Ryan J Protzko; Jennifer L Pluznick
Journal:  PLoS One       Date:  2014-10-23       Impact factor: 3.240

4.  Putative chemosensory receptors are differentially expressed in the sensory organs of male and female crown-of-thorns starfish, Acanthaster planci.

Authors:  R E Roberts; D Powell; T Wang; M H Hall; C A Motti; S F Cummins
Journal:  BMC Genomics       Date:  2018-11-29       Impact factor: 3.969

Review 5.  Olfactory Receptors in Non-Chemosensory Organs: The Nervous System in Health and Disease.

Authors:  Isidro Ferrer; Paula Garcia-Esparcia; Margarita Carmona; Eva Carro; Eleonora Aronica; Gabor G Kovacs; Alice Grison; Stefano Gustincich
Journal:  Front Aging Neurosci       Date:  2016-07-05       Impact factor: 5.750
  5 in total

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