Marco A R Vinolo1, Sandro M Hirabara, Rui Curi. 1. Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
Abstract
PURPOSE OF REVIEW: It has been demonstrated that fatty acids (FAs) are physiological ligands of G-protein-coupled receptors (GPRs). Activation of the GPRs (40, 41, 43, 84, 119 and 120) by FAs or synthetic agonists modulates several responses. In this review, we discuss the current knowledge on the actions of FA-activated GPRs and their relevance in normal and pathological conditions. RECENT FINDINGS: Studies have shown that FA-activated GPRs modulate hormone secretion (incretin, insulin and glucagon), activation of leukocytes and several aspects of metabolism. SUMMARY: Understanding GPR actions and their involvement in the development of insulin-resistance, β-cell failure, dyslipidemia and inflammation associated with obesity, type 2 diabetes, metabolic syndrome and cardiovascular diseases is important for the comprehension of the mechanisms underlying these pathological conditions and for the establishment of new and effective interventions.
PURPOSE OF REVIEW: It has been demonstrated that fatty acids (FAs) are physiological ligands of G-protein-coupled receptors (GPRs). Activation of the GPRs (40, 41, 43, 84, 119 and 120) by FAs or synthetic agonists modulates several responses. In this review, we discuss the current knowledge on the actions of FA-activated GPRs and their relevance in normal and pathological conditions. RECENT FINDINGS: Studies have shown that FA-activated GPRs modulate hormone secretion (incretin, insulin and glucagon), activation of leukocytes and several aspects of metabolism. SUMMARY: Understanding GPR actions and their involvement in the development of insulin-resistance, β-cell failure, dyslipidemia and inflammation associated with obesity, type 2 diabetes, metabolic syndrome and cardiovascular diseases is important for the comprehension of the mechanisms underlying these pathological conditions and for the establishment of new and effective interventions.
Authors: Laurent L'homme; Nathalie Esser; Laura Riva; André Scheen; Nicolas Paquot; Jacques Piette; Sylvie Legrand-Poels Journal: J Lipid Res Date: 2013-09-03 Impact factor: 5.922
Authors: Kathleen R Smith; Tania Hussain; Elnaz Karimian Azari; Jennifer L Steiner; Julio E Ayala; Richard E Pratley; George A Kyriazis Journal: Am J Physiol Endocrinol Metab Date: 2016-02-16 Impact factor: 4.310