Literature DB >> 25022758

Dock-family exchange factors in cell migration and disease.

Gilles Gadea1, Anne Blangy2.   

Abstract

Dock family proteins are evolutionary conserved exchange factors for the Rho GTPases Rac and Cdc42. There are 11 Dock proteins in mammals, named Dock1 (or Dock180) to Dock11 that play different cellular functions. In particular, Dock proteins regulate actin cytoskeleton, cell adhesion and migration. Not surprisingly, members of the Dock family have been involved in various pathologies, including cancer and defects in the central nervous and immune systems. This review proposes an update of the recent findings regarding the function of Dock proteins, focusing on their role in the control of cell migration and invasion and the consequences in human diseases.
Copyright © 2014 Elsevier GmbH. All rights reserved.

Entities:  

Keywords:  Adhesion; Amoeboid; Cancer; Cdc42; DHR2; Dock1; Dock10; Dock11; Dock180; Dock2; Dock3; Dock4; Dock5; Dock6; Dock7; Dock8; Dock9; Exchange factor; GPCR; Integrin; Migration; Osteoclast; Rac1; Rho GTPase; Synapse; Zizimin

Mesh：

Substances：

Year:  2014        PMID： 25022758     DOI： 10.1016/j.ejcb.2014.06.003

Source DB:  PubMed          Journal:  Eur J Cell Biol        ISSN： 0171-9335            Impact factor:   4.492


  81 in total

Review 1.  Targeting Rac and Cdc42 GTPases in Cancer.

Authors:  María Del Mar Maldonado; Suranganie Dharmawardhane
Journal:  Cancer Res       Date:  2018-06-01       Impact factor: 12.701

2.  Fine-Tuning of the Actin Cytoskeleton and Cell Adhesion During Drosophila Development by the Unconventional Guanine Nucleotide Exchange Factors Myoblast City and Sponge.

Authors:  Bridget Biersmith; Zong-Heng Wang; Erika R Geisbrecht
Journal:  Genetics       Date:  2015-04-23       Impact factor: 4.562

3.  Application of high-resolution array comparative genomic hybridization in children with unknown syndromic microcephaly.

Authors:  Eirini Tsoutsou; Maria Tzetis; Krinio Giannikou; Maria Braoudaki; Anastasis Mitrakos; Stella Amenta; Nikoletta Selenti; Emmanouil Kanavakis; Dimitrios Zafeiriou; Sophia Kitsiou-Tzeli; Helena Fryssira
Journal:  Pediatr Res       Date:  2017-05-24       Impact factor: 3.756

4.  Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant.

Authors:  Chao Liu; Theresa Guo; Guorong Xu; Akihiro Sakai; Shuling Ren; Takahito Fukusumi; Mizuo Ando; Sayed Sadat; Yuki Saito; Zubair Khan; Kathleen M Fisch; Joseph Califano
Journal:  Clin Cancer Res       Date:  2018-06-26       Impact factor: 12.531

5.  Spontaneous mutation of Dock7 results in lower trabecular bone mass and impaired periosteal expansion in aged female Misty mice.

Authors:  Phuong T Le; Kathleen A Bishop; David E Maridas; Katherine J Motyl; Daniel J Brooks; Kenichi Nagano; Roland Baron; Mary L Bouxsein; Clifford J Rosen
Journal:  Bone       Date:  2017-08-15       Impact factor: 4.398

6.  DOCK3-related neurodevelopmental syndrome: Biallelic intragenic deletion of DOCK3 in a boy with developmental delay and hypotonia.

Authors:  Aiko Iwata-Otsubo; Alyssa L Ritter; Brooke Weckselbatt; Nicole R Ryan; David Burgess; Laura K Conlin; Kosuke Izumi
Journal:  Am J Med Genet A       Date:  2017-11-12       Impact factor: 2.802

Review 7.  Rho GTPases: Regulation and roles in cancer cell biology.

Authors:  Raquel B Haga; Anne J Ridley
Journal:  Small GTPases       Date:  2016-09-14

8.  A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes.

Authors:  Tanja Arndt; Dirk Wedekind; Anne Jörns; Georgios Tsiavaliaris; Edwin Cuppen; Hans-Jürgen Hedrich; Sigurd Lenzen
Journal:  Diabetologia       Date:  2015-09-12       Impact factor: 10.122

9.  Expression of DOCK10.1 protein revealed with a specific antiserum: insights into regulation of first exon isoforms of DOCK10.

Authors:  Antonio Parrado
Journal:  Mol Biol Rep       Date:  2020-02-29       Impact factor: 2.316

10.  Systematic analysis to identify transcriptome-wide dysregulation of Alzheimer's disease in genes and isoforms.

Authors:  Cong Fan; Ken Chen; Jiaxin Zhou; Ping-Pui Wong; Dan He; Yiqi Huang; Xin Wang; Tianze Ling; Yuedong Yang; Huiying Zhao
Journal:  Hum Genet       Date:  2020-11-02       Impact factor: 4.132
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