| Literature DB >> 25022431 |
Douglas A MacKenzie1, Allison R Sherratt2, Mariya Chigrinova1, Lawrence L W Cheung1, John Paul Pezacki3.
Abstract
The development and applications of strain-promoted alkyne-nitrone cycloaddition (SPANC) reactions have brought about new tools for rapid and specific functionalization of biomolecules in different settings. While a number of strain-promoted reactions have been successfully developed, SPANC reactions offer high reactivity with bimolecular rate constants of k2 that are as fast as 60M(-1)s(-1). SPANC reactions also offer stability of starting materials, particularly in the case of endocyclic nitrones, as well as stereoelectronic tunability of the nitrone moiety to optimize reactivity towards different alkyne reaction partners. Herein we discuss recent advances in the development of SPANC reactions and their applications in bioorthogonal labeling. CrownEntities:
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Year: 2014 PMID： 25022431 DOI： 10.1016/j.cbpa.2014.05.023
Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822