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Literature DB >> 25019368

CCR7: roles in cancer cell dissemination, migration and metastasis formation.

Daniel F Legler¹, Edith Uetz-von Allmen², Mark A Hauser².

Abstract

The CC-chemokine receptor 7 (CCR7) coordinates the migration of cancer cells as well as immune cells towards lymphatic organs where its two ligands CCL19 and CCL21 are constitutively expressed. Here we provide a topological model of CCR7, which belongs to the class A of G-protein coupled, seven-transmembrane spanning receptors, and describe how CCR7 expression is regulated. We focus on its role in cancer cell migration and metastasis formation and discuss how cancer cells can utilize CCR7 or its ligands to escape from immune surveillance.

Entities: Chemical

Keywords: Cancer; Cell migration; Chemokine receptor; Lymph node homing; Metastasis formation

Mesh：

Substances：
Receptors, CCR7

Year: 2014 PMID： 25019368 DOI： 10.1016/j.biocel.2014.07.002

Source DB: PubMed Journal: Int J Biochem Cell Biol ISSN： 1357-2725 Impact factor: 5.085

Keyword Cloud
Cited

28 in total

1. Production of Recombinant Chemokines and Validation of Refolding.

Authors: Christopher T Veldkamp; Chad A Koplinski; Davin R Jensen; Francis C Peterson; Kaitlin M Smits; Brittney L Smith; Scott K Johnson; Christina Lettieri; Wallace G Buchholz; Joyce C Solheim; Brian F Volkman
Journal: Methods Enzymol Date: 2015-11-14 Impact factor: 1.600

2. Two independent but synchronized Gβγ subunit-controlled pathways are essential for trailing-edge retraction during macrophage migration.

Authors: Praneeth Siripurapu; Dinesh Kankanamge; Kasun Ratnayake; Kanishka Senarath; Ajith Karunarathne
Journal: J Biol Chem Date: 2017-09-01 Impact factor: 5.157

3. Association of chemokine and chemokine receptor expression with the invasion and metastasis of lung carcinoma.

Authors: Yan Liu; Bing-Quan Wu; Hua Geng; Mei-Lin Xu; Hao-Hao Zhong
Journal: Oncol Lett Date: 2015-06-22 Impact factor: 2.967

4. CCR7 pathway induces epithelial-mesenchymal transition through up-regulation of Snail signaling in gastric cancer.

Authors: Jianping Zhang; Yunzhe Zhou; Yonggang Yang
Journal: Med Oncol Date: 2015-01-09 Impact factor: 3.064

Review 5. The Multi-Functional Roles of CCR7 in Human Immunology and as a Promising Therapeutic Target for Cancer Therapeutics.

Authors: Faris Alrumaihi
Journal: Front Mol Biosci Date: 2022-07-06

Review 6. Therapeutic Lymphoid Organogenesis in the Tumor Microenvironment.

Authors: Aliyah M Weinstein; Walter J Storkus
Journal: Adv Cancer Res Date: 2015-05-05 Impact factor: 6.242

7. Solution Structure of CCL19 and Identification of Overlapping CCR7 and PSGL-1 Binding Sites.

Authors: Christopher T Veldkamp; Eva Kiermaier; Skylar J Gabel-Eissens; Miranda L Gillitzer; David R Lippner; Frank A DiSilvio; Casey J Mueller; Paeton L Wantuch; Gary R Chaffee; Michael W Famiglietti; Danielle M Zgoba; Asha A Bailey; Yaya Bah; Samantha J Engebretson; David R Graupner; Emily R Lackner; Vincent D LaRosa; Tysha Medeiros; Michael L Olson; Andrew J Phillips; Harley Pyles; Amanda M Richard; Scott J Schoeller; Boris Touzeau; Larry G Williams; Michael Sixt; Francis C Peterson
Journal: Biochemistry Date: 2015-07-06 Impact factor: 3.162