| Literature DB >> 26115234 |
Christopher T Veldkamp1,2, Eva Kiermaier3, Skylar J Gabel-Eissens1, Miranda L Gillitzer1, David R Lippner1, Frank A DiSilvio1, Casey J Mueller1, Paeton L Wantuch1, Gary R Chaffee1, Michael W Famiglietti1, Danielle M Zgoba1, Asha A Bailey1, Yaya Bah1, Samantha J Engebretson1, David R Graupner1, Emily R Lackner1, Vincent D LaRosa1, Tysha Medeiros1, Michael L Olson1, Andrew J Phillips1, Harley Pyles1, Amanda M Richard1, Scott J Schoeller1, Boris Touzeau1, Larry G Williams1, Michael Sixt3, Francis C Peterson2.
Abstract
CCL19 and CCL21 are chemokines involved in the trafficking of immune cells, particularly within the lymphatic system, through activation of CCR7. Concurrent expression of PSGL-1 and CCR7 in naive T-cells enhances recruitment of these cells to secondary lymphoid organs by CCL19 and CCL21. Here the solution structure of CCL19 is reported. It contains a canonical chemokine domain. Chemical shift mapping shows the N-termini of PSGL-1 and CCR7 have overlapping binding sites for CCL19 and binding is competitive. Implications for the mechanism of PSGL-1's enhancement of resting T-cell recruitment are discussed.Entities:
Mesh：
Substances：
Year: 2015 PMID： 26115234 PMCID： PMC4809050 DOI： 10.1021/acs.biochem.5b00560
Source DB: PubMed Journal: Biochemistry ISSN： 0006-2960 Impact factor: 3.162