DETECHIP has been used in testing analytes including caffeine, cocaine, and tetrahydrocannabinol (THC) from marijuana, as well as date rape and club drugs such as flunitrazepam, gamma-hydroxybutyric acid (GHB), and methamphetamine. This study investigates the intermolecular interaction between DETECHIP sensor eosin Y (DC1) and the analyte (caffeine) that is responsible for the fluorescence and color changes observed in the actual array. Using 1H-NMR, 1H-COSY, and 1H-DOSY NMR methods, a proton exchange from C-8 of caffeine to eosin Y is proposed.
DETECHIP has been used in testing analytes including n class="Chemical">caffeine, cocaine, and tetrahydrocannabinol (THC) from marijuana, as well as date rape and club drugs such as flunitrazepam, gamma-hydroxybutyric acid (GHB), and methamphetamine. This study investigates the intermolecular interaction between DETECHIP sensor eosin Y (DC1) and the analyte (caffeine) that is responsible for the fluorescence and color changes observed in the actual array. Using 1H-NMR, 1H-COSY, and 1H-DOSY NMR methods, a proton exchange from C-8 of caffeine to eosin Y is proposed.
Authors: Raychelle M Burks; Shari E Pacquette; Mike A Guericke; Mark V Wilson; David J Symonsbergen; Kerry A Lucas; Andrea E Holmes Journal: J Forensic Sci Date: 2010-02-25 Impact factor: 1.832
Authors: A Negrusz; C Moore; D Deitermann; D Lewis; K Kaleciak; R Kronstrand; B Feeley; R S Niedbala Journal: J Anal Toxicol Date: 1999-10 Impact factor: 3.367