| Literature DB >> 25017503 |
N C van Wouwe1, W P M van den Wildenberg2, D O Claassen3, K Kanoff3, T R Bashore4, S A Wylie3.
Abstract
The current study investigated the effects of Parkinson's disease (PD) on the ability to resolve conflicts when performance emphasized speed vs. response accuracy. PD patients and healthy controls (HC) completed a Simon task, and a subset of participants provided movement-related potential (MRP) data to investigate motor cortex activation and inhibition associated with conflict resolution. Both groups adjusted performance strategically with speed or accuracy instructions. The groups experienced similar susceptibility to making fast errors in conflict trials, but PD patients were less proficient compared to HC at suppressing incorrect responses, especially under speed pressure. Analysis of MRPs showed attenuated inhibition of the motor cortex controlling the conflicting response in PD patients compared to HC. These results confirm the detrimental effects of PD on inhibitory control mechanisms with speed pressure and also suggest that a downstream effect of inhibitory dysfunction in PD might be due to diminished inhibition of the motor cortex.Entities:
Keywords: Dual Processing Activation–Suppression model; Event related motor potentials; Inhibitory control; Laplacian; Parkinson's disease; Speed–accuracy trade off
Mesh：
Year: 2014 PMID： 25017503 PMCID： PMC4504191 DOI： 10.1016/j.biopsycho.2014.07.002
Source DB: PubMed Journal: Biol Psychol ISSN： 0301-0511 Impact factor: 3.251