Literature DB >> 25017019

cCMP is a substrate for MRP5.

Svenja Laue1, Moritz Winterhoff, Volkhard Kaever, Jeroen J van den Heuvel, Frans G Russel, Roland Seifert.   

Abstract

The cyclic pyrimidine nucleotide cCMP has been suggested to serve as second messenger. However, phosphodiesterases studied so far do not hydrolyze cCMP. Therefore, we searched for alternative cCMP inactivation mechanisms. cCMP is a substrate for multidrug resistance protein 5, indicating that export from the cytosol into the extracellular space is an important inactivation mechanism for cCMP.

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Year:  2014        PMID： 25017019     DOI： 10.1007/s00210-014-1018-9

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  18 in total

1.  Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1, MRP2, MRP3, and MRP4.

Authors:  Hanneke G M Wittgen; Jeroen J M W van den Heuvel; Petra H H van den Broek; Heike Dinter-Heidorn; Jan B Koenderink; Frans G M Russel
Journal:  Drug Metab Dispos       Date:  2011-04-21       Impact factor: 3.922

2.  Nucleotidyl cyclase activity of soluble guanylyl cyclase α1β1.

Authors:  Kerstin Y Beste; Heike Burhenne; Volkhard Kaever; Johannes-Peter Stasch; Roland Seifert
Journal:  Biochemistry       Date:  2011-12-13       Impact factor: 3.162

3.  Soluble adenylyl cyclase accounts for high basal cCMP and cUMP concentrations in HEK293 and B103 cells.

Authors:  Alan Hasan; Kerstin Y Danker; Sabine Wolter; Heike Bähre; Volkhard Kaever; Roland Seifert
Journal:  Biochem Biophys Res Commun       Date:  2014-04-30       Impact factor: 3.575

Review 4.  Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy.

Authors:  Dietrich Keppler
Journal:  Handb Exp Pharmacol       Date:  2011

Review 5.  Cellular efflux of cAMP and cGMP - a question about selectivity.

Authors:  Georg Sager; Aina Westrheim Ravna
Journal:  Mini Rev Med Chem       Date:  2009-07       Impact factor: 3.862

Review 6.  Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules.

Authors:  Frans G M Russel; Jan B Koenderink; Rosalinde Masereeuw
Journal:  Trends Pharmacol Sci       Date:  2008-03-18       Impact factor: 14.819

7.  Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP.

Authors:  Cheryl D Cropp; Takafumi Komori; James E Shima; Thomas J Urban; Sook Wah Yee; Swati S More; Kathleen M Giacomini
Journal:  Mol Pharmacol       Date:  2008-01-23       Impact factor: 4.436

8.  Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain.

Authors:  Ivar von Kügelgen; Anke C Schiedel; Kristina Hoffmann; Bernt B A Alsdorf; Aliaa Abdelrahman; Christa E Müller
Journal:  Mol Pharmacol       Date:  2007-11-01       Impact factor: 4.436

Review 9.  Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides.

Authors:  R Seifert; G Schultz
Journal:  Trends Pharmacol Sci       Date:  1989-09       Impact factor: 14.819

10.  ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation.

Authors:  Urike Beckert; Sabine Wolter; Christina Hartwig; Heike Bähre; Volkhard Kaever; Daniel Ladant; Dara W Frank; Roland Seifert
Journal:  Biochem Biophys Res Commun       Date:  2014-06-24       Impact factor: 3.575
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  12 in total

1.  cCMP and cUMP occur in vivo.

Authors:  Heike Bähre; Christina Hartwig; Antje Munder; Sabine Wolter; Tane Stelzer; Bastian Schirmer; Ulrike Beckert; Dara W Frank; Burkhard Tümmler; Volkhard Kaever; Roland Seifert
Journal:  Biochem Biophys Res Commun       Date:  2015-03-31       Impact factor: 3.575

2.  cUMP hydrolysis by PDE3A.

Authors:  Stefan Berrisch; Jessica Ostermeyer; Volkhard Kaever; Solveig Kälble; Denise Hilfiker-Kleiner; Roland Seifert; Erich H Schneider
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2016-12-14       Impact factor: 3.000

3.  Recent progress in the field of cIMP research.

Authors:  Roland Seifert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2016-08-18       Impact factor: 3.000

4.  Naunyn-Schmiedeberg's Archives of Pharmacology under new editorship: change and continuity.

Authors:  Roland Seifert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2016-05-24       Impact factor: 3.000

5.  cUMP hydrolysis by PDE3B.

Authors:  Jessica Ostermeyer; Franziska Golly; Volkhard Kaever; Stefan Dove; Roland Seifert; Erich H Schneider
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2018-05-28       Impact factor: 3.000

6.  N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids.

Authors:  Robert S Jansen; Ruben Addie; Remco Merkx; Alexander Fish; Sunny Mahakena; Onno B Bleijerveld; Maarten Altelaar; Lodewijk IJlst; Ronald J Wanders; P Borst; Koen van de Wetering
Journal:  Proc Natl Acad Sci U S A       Date:  2015-05-11       Impact factor: 11.205

7.  Heterogeneity of pulmonary endothelial cyclic nucleotide response to Pseudomonas aeruginosa ExoY infection.

Authors:  K A Morrow; R Seifert; V Kaever; A L Britain; S L Sayner; C D Ochoa; E A Cioffi; D W Frank; T C Rich; T Stevens
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2015-09-18       Impact factor: 5.464

8.  Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode.

Authors:  Jessica Scharrenbroich; Volkhard Kaever; Stefan Dove; Roland Seifert; Erich H Schneider
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2018-11-15       Impact factor: 3.000

9.  N4-monobutyryl-cCMP activates PKA RIα and PKA RIIα more potently and with higher efficacy than PKG Iα in vitro but not in vivo.

Authors:  Sabine Wolter; Stefan Dove; Marina Golombek; Frank Schwede; Roland Seifert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2014-09-06       Impact factor: 3.000

10.  The Pseudomonas aeruginosa ExoY phenotype of high-copy-number recombinants is not detectable in natural isolates.

Authors:  Antje Munder; Justin Rothschuh; Bastian Schirmer; Jens Klockgether; Volkhard Kaever; Burkhard Tümmler; Roland Seifert; Christina Kloth
Journal:  Open Biol       Date:  2018-01       Impact factor: 6.411
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