Literature DB >> 19601896

Cellular efflux of cAMP and cGMP - a question about selectivity.

Georg Sager1, Aina Westrheim Ravna.   

Abstract

The present paper reviews and discusses selectivity of ABCC4 (MRP4), ABCC5 (MRP5) and ABCC11 (MRP8) as cellular efflux pumps for cAMP and cGMP. These transporters are potential drug targets for selective modulation of cyclic nucleotide action.

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Year:  2009        PMID： 19601896     DOI： 10.2174/138955709788681654

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  18 in total

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Authors:  Ross Corriden; Paul A Insel
Journal:  Purinergic Signal       Date:  2012-04-15       Impact factor: 3.765

2.  Quantification of cAMP and cGMP analogs in intact cells: pitfalls in enzyme immunoassays for cyclic nucleotides.

Authors:  Katharina Werner; Frank Schwede; Hans-Gottfried Genieser; Jörg Geiger; Elke Butt
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2011-06-29       Impact factor: 3.000

3.  Novel cGMP efflux inhibitors identified by virtual ligand screening (VLS) and confirmed by experimental studies.

Authors:  Georg Sager; Elin Ø Ørvoll; Roy A Lysaa; Irina Kufareva; Ruben Abagyan; Aina W Ravna
Journal:  J Med Chem       Date:  2012-03-20       Impact factor: 7.446

4.  8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphate-Na stimulates human alveolar fluid clearance by releasing external Na+ self-inhibition of epithelial Na+ channels.

Authors:  Dong-Yun Han; Hong-Guang Nie; Xue-Feng Su; Xue-Mei Shi; Deepa Bhattarai; Meimi Zhao; Run-Zhen Zhao; Katlin Landers; Hua Tang; Lin Zhang; Hong-Long Ji
Journal:  Am J Respir Cell Mol Biol       Date:  2011-05-11       Impact factor: 6.914

5.  Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation.

Authors:  Sabrina Copsel; Corina Garcia; Federico Diez; Monica Vermeulem; Alberto Baldi; Liliana G Bianciotti; Frans G M Russel; Carina Shayo; Carlos Davio
Journal:  J Biol Chem       Date:  2011-01-04       Impact factor: 5.157

6.  ABCC5 is required for cAMP-mediated hindgut invagination in sea urchin embryos.

Authors:  Lauren E Shipp; Rose Z Hill; Gary W Moy; Tufan Gökırmak; Amro Hamdoun
Journal:  Development       Date:  2015-09-22       Impact factor: 6.868

7.  Urethral dysfunction in a rat model of chemically induced prostatic inflammation: potential involvement of the MRP5 pump.

Authors:  Eduardo C Alexandre; Nailong Cao; Shinsuke Mizoguchi; Tetsuichi Saito; Masahiro Kurobe; Daisuke Gotoh; Meri Okorie; Taro Igarashi; Edson Antunes; Naoki Yoshimura
Journal:  Am J Physiol Renal Physiol       Date:  2020-02-10

8.  Vascular pathology of medial arterial calcifications in NT5E deficiency: implications for the role of adenosine in pseudoxanthoma elasticum.

Authors:  Thomas C Markello; Laura K Pak; Cynthia St Hilaire; Heidi Dorward; Shira G Ziegler; Marcus Y Chen; Krishna Chaganti; Robert L Nussbaum; Manfred Boehm; William A Gahl
Journal:  Mol Genet Metab       Date:  2011-02-03       Impact factor: 4.797

9.  Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea.

Authors:  Changsuk Moon; Weiqiang Zhang; Aixia Ren; Kavisha Arora; Chandrima Sinha; Sunitha Yarlagadda; Koryse Woodrooffe; John D Schuetz; Koteswara Rao Valasani; Hugo R de Jonge; Shiva Kumar Shanmukhappa; Mohamed Tarek M Shata; Randal K Buddington; Kaushik Parthasarathi; Anjaparavanda P Naren
Journal:  J Biol Chem       Date:  2015-03-11       Impact factor: 5.157

10.  cCMP is a substrate for MRP5.

Authors:  Svenja Laue; Moritz Winterhoff; Volkhard Kaever; Jeroen J van den Heuvel; Frans G Russel; Roland Seifert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2014-07-15       Impact factor: 3.000
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