Literature DB >> 25016952

Iridoid glycosides isolated from Scrophularia dentata Royle ex Benth. and their anti-inflammatory activity.

Liuqiang Zhang1, Tiantian Zhu1, Fei Qian1, Jinwen Xu2, Gaawe Dorje3, Zhili Zhao1, Fujiang Guo4, Yiming Li5.   

Abstract

Scrodentosides A-E (1-5), five new acylated iridoid glycosides, together with 19 known ones, were isolated from the whole plant of Scrophularia dentata Royle ex Benth. The structures of these isolated glycosides were elucidated by spectroscopic methods. Bioassay showed that compounds 7 and 11 had significant inhibitory effect against NF-κB activation with IC50 value of 43.7 μM and 1.02 μM respectively.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  8-O-acetylharpagide (PubChem CID: 160879); Ajugol(PubChem CID: 6452750); Ajugoside (PubChem CID: 179611); Anti-inflammation; Cis-harpagoside (PubChem CID: 13889700); Geniposidic acid(PubChem CID: 443354); Iridoid glycosides; NF-κB; Scrophularia dentata; Scropolioside D (PubChem CID: 6918700); Trans-harpagoside (PubChem CID: 5281542); harpagide (PubChem CID: 93045)

Mesh：

Substances：

Year:  2014        PMID： 25016952     DOI： 10.1016/j.fitote.2014.07.005

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  8 in total

1.  Scrodentoids H and I, a Pair of Natural Epimerides from Scrophularia dentata, Inhibit Inflammation through JNK-STAT3 Axis in THP-1 Cells.

Authors:  Gaohui Mao; Liqin Sun; Jinwen Xu; Yiming Li; Ciren Dunzhu; Liuqiang Zhang; Fei Qian
Journal:  Evid Based Complement Alternat Med       Date:  2020-07-27       Impact factor: 2.629

2.  The Complete Chloroplast Genome of Ye-Xing-Ba (Scrophularia dentata; Scrophulariaceae), an Alpine Tibetan Herb.

Authors:  Lianghong Ni; Zhili Zhao; Gaawe Dorje; Mi Ma
Journal:  PLoS One       Date:  2016-07-08       Impact factor: 3.240

Review 3.  The genus Scrophularia: a source of iridoids and terpenoids with a diverse biological activity.

Authors:  Ardalan Pasdaran; Azadeh Hamedi
Journal:  Pharm Biol       Date:  2017-12       Impact factor: 3.503

4.  Simultaneous Determination of Seven Components in Rat Plasma by the UPLC-MS/MS Method and Application of Pharmacokinetic Studies to SimiaoYong'an Decoction.

Authors:  Yuanyan Liu; Sensen Chi; Weihua Wang; Lei Su; Bin Liu
Journal:  Molecules       Date:  2017-11-09       Impact factor: 4.411

5.  Acetylharpagide Protects Mice from Staphylococcus Aureus-Induced Acute Lung Injury by Inhibiting NF-κB Signaling Pathway.

Authors:  Zhaoxin Zhang; Yun Wang; Yating Shan; Wu Yin
Journal:  Molecules       Date:  2020-11-25       Impact factor: 4.411

6.  Plio-Pleistocene climatic change drives allopatric speciation and population divergence within the Scrophularia incisa complex (Scrophulariaceae) of desert and steppe subshrubs in Northwest China.

Authors:  Rui-Hong Wang; Zhao-Ping Yang; Zhi-Cheng Zhang; Hans Peter Comes; Zhe-Chen Qi; Pan Li; Cheng-Xin Fu
Journal:  Front Plant Sci       Date:  2022-09-21       Impact factor: 6.627

7.  Cytotoxic and Apoptotic Activities of Methanolic Subfractions of Scrophularia oxysepala against Human Breast Cancer Cell Line.

Authors:  Mona Orangi; Ardalan Pasdaran; Dariush Shanehbandi; Tohid Kazemi; Bahman Yousefi; Behnaz-Alsadat Hosseini; Behzad Baradaran
Journal:  Evid Based Complement Alternat Med       Date:  2016-02-29       Impact factor: 2.629

8.  Scrophularia Tenuipes Coss and Durieu: Phytochemical Composition and Biological Activities.

Authors:  Zeyneb Chaibeddra; Salah Akkal; Houria Ouled-Haddar; Artur M S Silva; Ammar Zellagui; Mohamed Sebti; Susana M Cardoso
Journal:  Molecules       Date:  2020-04-03       Impact factor: 4.411
  8 in total

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