Eun Chul Kim1, Kyungdo Han2, Donghyun Jee3. 1. Department of Ophthalmology and Visual Science, Buchon St. Mary's Hospital, College of Medicine, Catholic University of Korea, Buchon, Korea. 2. Department of Biostatistics, Department of Preventive Medicine, College of Medicine, Catholic University of Korea, Seoul, Korea. 3. Department of Ophthalmology and Visual Science, St. Vincent's Hospital, College of Medicine, Catholic University of Korea, Suwon, Korea.
Abstract
PURPOSE: To investigate the association of 25-hydroxyvitamin D with AMD. METHODS: A population-based, cross-sectional study using a nationwide, systemic-stratified, multistage-clustered sampling method involved a total of 17,045 subjects older than 40 years who participated in the Korean National Health and Nutrition Examination Survey 2008 to 2012. All participants underwent standardized interviews, evaluation of blood 25-hydroxyvitamin D levels, and comprehensive ophthalmic examinations. A 45° digital fundus photograph of both eyes was taken under physiologic mydriasis. All fundus photographs were graded using the international classification and grading system. RESULTS: Blood 25-hydroxyvitamin D levels were 17.5 ng/mL in women and 20.0 ng/mL in men. After adjusting for potential confounders including age, sex, smoking status, hypertension, heart problems, stroke, and sunlight-exposure time, the odds ratio (OR) for late AMD significantly decreased in the highest blood 25-hydroxyvitamin D quintile (OR, 0.32; 95% confidence interval [CI], 0.12-0.81; P for trend = 0.018) compared with the lowest quintile in men, but not in women. Early AMD was not associated with blood 25-hydroxyvitamin D levels in either sex. CONCLUSIONS: High level of blood 25-hydroxyvitamin D was inversely associated with late AMD in men but not women. Considering antiangiogenic and antifibrotic action of vitamin D, association between two variables warrants further studies. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
PURPOSE: To investigate the association of 25-hydroxyvitamin D with AMD. METHODS: A population-based, cross-sectional study using a nationwide, systemic-stratified, multistage-clustered sampling method involved a total of 17,045 subjects older than 40 years who participated in the Korean National Health and Nutrition Examination Survey 2008 to 2012. All participants underwent standardized interviews, evaluation of blood 25-hydroxyvitamin D levels, and comprehensive ophthalmic examinations. A 45° digital fundus photograph of both eyes was taken under physiologic mydriasis. All fundus photographs were graded using the international classification and grading system. RESULTS: Blood 25-hydroxyvitamin D levels were 17.5 ng/mL in women and 20.0 ng/mL in men. After adjusting for potential confounders including age, sex, smoking status, hypertension, heart problems, stroke, and sunlight-exposure time, the odds ratio (OR) for late AMD significantly decreased in the highest blood 25-hydroxyvitamin D quintile (OR, 0.32; 95% confidence interval [CI], 0.12-0.81; P for trend = 0.018) compared with the lowest quintile in men, but not in women. Early AMD was not associated with blood 25-hydroxyvitamin D levels in either sex. CONCLUSIONS: High level of blood 25-hydroxyvitamin D was inversely associated with late AMD in men but not women. Considering antiangiogenic and antifibrotic action of vitamin D, association between two variables warrants further studies. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
Entities:
Keywords:
25-hydroxyvitamin D; Korea; age-related macular degeneration; sex difference
Authors: A E Millen; J Nie; M W Sahli; J A Mares; K J Meyers; B E K Klein; M J LaMonte; P L Lutsey; C A Andrews; R Klein Journal: J Nutr Health Aging Date: 2017 Impact factor: 4.075
Authors: Kyung Chul Yoon; Won Choi; Hyo Seok Lee; Sang-Duck Kim; Seung-Hyun Kim; Chan Yun Kim; Ki Ho Park; Young Jeung Park; Seung-Hee Baek; Su Jeong Song; Jae Pil Shin; Suk-Woo Yang; Seung-Young Yu; Jong Soo Lee; Key Hwan Lim; Kyung Won Oh; Se Woong Kang Journal: Korean J Ophthalmol Date: 2015-11-25
Authors: Alfredo Garcia Layana; Angelo Maria Minnella; Gerhard Garhöfer; Tariq Aslam; Frank G Holz; Anita Leys; Rufino Silva; Cécile Delcourt; Eric Souied; Johanna M Seddon Journal: Nutrients Date: 2017-10-13 Impact factor: 5.717