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Literature DB >> 25014741

The aging bone marrow and its impact on immune responses in old age.

Theresa Pritz¹, Birgit Weinberger¹, Beatrix Grubeck-Loebenstein².

Abstract

With aging the immune system undergoes significant age-related changes. These age-dependent changes are referred to as immunosenescence and are partially responsible for the poor immune response to infections and the low efficacy of vaccination in elderly persons. Immunosenescence is characterized by a decrease in innate and adaptive cell-mediated immune function in the peripheral blood and the bone marrow. The aging of bone marrow cells and in particular, of adaptive immune cells in the bone marrow has been addressed relatively rarely. It is therefore the goal of this review to summarize what is known about the effect of age on bone marrow immune cells and their precursors in mice and humans.

Entities: Disease Species

Keywords: Age; Bone marrow; Memory T cells; Plasma cells; Survival niche

Mesh：

Year: 2014 PMID： 25014741 DOI： 10.1016/j.imlet.2014.06.016

Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685

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Cited

28 in total

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2. From the Cover: Tributyltin Alters the Bone Marrow Microenvironment and Suppresses B Cell Development.

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Journal: Toxicol Sci Date: 2017-07-01 Impact factor: 4.849

Review 3. Checkpoint Inhibitors for Non-Small Cell Lung Cancer Among Older Adults.

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4. Progressive ossification of the bone marrow vasculature with advancing age corresponds with reduced red blood cell count and percentage of circulating lymphocytes in male Fischer-344 rats.

Authors: Sophie Guderian; Seungyong Lee; Mary Ann McLane; Rhonda D Prisby
Journal: Microcirculation Date: 2019-06-17 Impact factor: 2.628

5. Effects of a 12-Week Multimodal Exercise Intervention Among Older Patients with Advanced Cancer: Results from a Randomized Controlled Trial.

Authors: Marta K Mikkelsen; Cecilia M Lund; Anders Vinther; Anders Tolver; Julia S Johansen; Inna Chen; Anne-Mette Ragle; Bo Zerahn; Lotte Engell-Noerregaard; Finn O Larsen; Susann Theile; Dorte L Nielsen; Mary Jarden
Journal: Oncologist Date: 2022-02-03 Impact factor: 5.837

The aging bone marrow and its impact on immune responses in old age.

Review 1. Challenges with Diagnosing and Managing Sepsis in Older Adults.

2. From the Cover: Tributyltin Alters the Bone Marrow Microenvironment and Suppresses B Cell Development.

Review 3. Checkpoint Inhibitors for Non-Small Cell Lung Cancer Among Older Adults.

4. Progressive ossification of the bone marrow vasculature with advancing age corresponds with reduced red blood cell count and percentage of circulating lymphocytes in male Fischer-344 rats.

5. Effects of a 12-Week Multimodal Exercise Intervention Among Older Patients with Advanced Cancer: Results from a Randomized Controlled Trial.

6. The effects of red cell transfusion donor age on nosocomial infection among trauma patients.

Review 7. The ageing human B cell repertoire: a failure of selection?

Review 8. Safety of Antithrombotic Agents in Elderly Patients with Acute Coronary Syndromes.

9. Impaired Immune Response in Elderly Burn Patients: New Insights Into the Immune-senescence Phenotype.

10. Improved function and balance in T cell modulation by endothelial cells in young people.