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Literature DB >> 2501473

Ethanol: water mutually enhanced transdermal therapeutic system II: skin permeation of ethanol and nitroglycerin.

B Berner¹, G C Mazzenga, J H Otte, R J Steffens, R H Juang, C D Ebert.

Abstract

An optimal concentration range of aqueous ethanol produces 5-10-fold increases in nitroglycerin flux across skin and ethanol skin permeation that are far greater than reported previously. For aqueous ethanol solutions saturated with nitroglycerin with an ethanol volume fraction less than or equal to 0.7, the flux of nitroglycerin across skin is linear with the ethanol flux and is traced to a linear solubility relationship and a constant diffusion coefficient.

Entities: Chemical

Mesh：

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Year: 1989 PMID： 2501473 DOI： 10.1002/jps.2600780512

Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534

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Cited

20 in total

1. Physical and chemical permeation enhancers in transdermal delivery of terbutaline sulphate.

Authors: S N Murthy; S R Hiremath
Journal: AAPS PharmSciTech Date: 2001-02-15 Impact factor: 3.246

2. Effects of transdermal penetration enhancers on the permeability of shed snakeskin.

Authors: T Itoh; L Wasinger; T M Turunen; J H Rytting
Journal: Pharm Res Date: 1992-09 Impact factor: 4.200

3. Feasibility of transdermal delivery of fluoxetine.

Authors: Darshan K Parikh; Tapash K Ghosh
Journal: AAPS PharmSciTech Date: 2005-09-30 Impact factor: 3.246

4. Cotransport of estradiol and ethanol through human skin in vitro: understanding the permeant/enhancer flux relationship.

Authors: P Liu; T Kurihara-Bergstrom; W R Good
Journal: Pharm Res Date: 1991-07 Impact factor: 4.200

9. An integrated pharmacokinetic and imaging evaluation of vehicle effects on solute human epidermal flux and, retention characteristics.

Authors: G Winckle; Y G Anissimov; S E Cross; G Wise; M S Roberts
Journal: Pharm Res Date: 2007-09-22 Impact factor: 4.200

10. Variational analysis of the transdermal delivery rate from two prototypical ethanol-water nitroglycerin TTS devices and Transderm-Nitro 10 in the normal population.

Authors: G M Kochak; B Berner; M Leal; N C Sambol
Journal: J Pharmacokinet Biopharm Date: 1992-10

Ethanol: water mutually enhanced transdermal therapeutic system II: skin permeation of ethanol and nitroglycerin.

1. Physical and chemical permeation enhancers in transdermal delivery of terbutaline sulphate.

2. Effects of transdermal penetration enhancers on the permeability of shed snakeskin.

3. Feasibility of transdermal delivery of fluoxetine.

4. Cotransport of estradiol and ethanol through human skin in vitro: understanding the permeant/enhancer flux relationship.

5. Lipid extracting effect on ethanol on keratinized oral mucosa.

Review 6. Getting Drugs Across Biological Barriers.

7. Percutaneous penetration modifiers and formulation effects: thermal and spectral analyses.

Review 8. Pharmacokinetic characterisation of transdermal delivery systems.

9. An integrated pharmacokinetic and imaging evaluation of vehicle effects on solute human epidermal flux and, retention characteristics.

10. Variational analysis of the transdermal delivery rate from two prototypical ethanol-water nitroglycerin TTS devices and Transderm-Nitro 10 in the normal population.