Alexandre R Zlotta1, Shin Egawa2, Dmitry Pushkar3, Alexander Govorov3, Takahiro Kimura2, Masahito Kido2, Hiroyuki Takahashi2, Cynthia Kuk4, Marta Kovylina3, Najla Aldaoud5, Neil Fleshner6, Antonio Finelli6, Laurence Klotz7, Gina Lockwood8, Jenna Sykes9, Theodorus van der Kwast10. 1. Department of Surgery, Division of Urology, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Surgical Oncology, Division of Urology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Electronic address: azlotta@mtsinai.on.ca. 2. Department of Urology, Jikei University School of Medicine, Tokyo, Japan. 3. Department of Urology, Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia. 4. Department of Surgery, Division of Urology, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Surgical Oncology, Division of Urology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. 5. Department of Pathology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; Department of Pathology and Microbiology, Jordan University of Science and Technology, Irbid, Jordan. 6. Department of Surgical Oncology, Division of Urology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. 7. Division of Urology, Sunnybrook and Women's Health Science Centre, Toronto, Ontario, Canada. 8. Department of Surgical Oncology, Division of Urology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network Toronto, Ontario, Canada. 9. Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network Toronto, Ontario, Canada. 10. Department of Pathology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
Abstract
UNLABELLED: Inflammation has been suggested to be involved in the pathogenesis of benign prostatic hyperplasia (BPH). We studied the prevalence of inflammation and BPH in Asian and Caucasian men on prostate glands (n=320) obtained during autopsy in Moscow, Russia (Caucasian men, n=220), and Tokyo, Japan (Asian men, n=100). We correlated the presence and grade of acute inflammation (AI) or chronic inflammation (CI) and BPH. AI, CI, and histologic BPH were analyzed in a blinded fashion using a grading system (0-3). We used the Cochran-Armitage test for associations between the degree of BPH and clinical variables and proportional odds logistic regression models in multivariable analysis. Histologic BPH was observed in a similar proportion of Asian and Caucasian men (p=0.94). CI was found in>70% of men in both the Asian and Caucasian groups (p>0.05). Higher BPH scores were associated with more CI (p<0.001). In multivariate analyses, individuals with CI were 6.8 times more likely to have a higher BPH score than individuals without (p<0.0001). Men included in this study presented at the hospital and their symptomatic status was not known. The prevalence of CI and BPH on autopsy is similar in Asian and Caucasian men despite very different diet and lifestyle. CI is strongly associated in both groups with BPH. PATIENT SUMMARY: In this study, we looked at the prevalence of inflammation and benign prostatic hyperplasia (BPH) on autopsy in Asian and Caucasian men. We found chronic inflammation in>70% of men on autopsy. More chronic inflammation was associated with more BPH.
UNLABELLED: Inflammation has been suggested to be involved in the pathogenesis of benign prostatic hyperplasia (BPH). We studied the prevalence of inflammation and BPH in Asian and Caucasian men on prostate glands (n=320) obtained during autopsy in Moscow, Russia (Caucasian men, n=220), and Tokyo, Japan (Asian men, n=100). We correlated the presence and grade of acute inflammation (AI) or chronic inflammation (CI) and BPH. AI, CI, and histologic BPH were analyzed in a blinded fashion using a grading system (0-3). We used the Cochran-Armitage test for associations between the degree of BPH and clinical variables and proportional odds logistic regression models in multivariable analysis. Histologic BPH was observed in a similar proportion of Asian and Caucasian men (p=0.94). CI was found in>70% of men in both the Asian and Caucasian groups (p>0.05). Higher BPH scores were associated with more CI (p<0.001). In multivariate analyses, individuals with CI were 6.8 times more likely to have a higher BPH score than individuals without (p<0.0001). Men included in this study presented at the hospital and their symptomatic status was not known. The prevalence of CI and BPH on autopsy is similar in Asian and Caucasian men despite very different diet and lifestyle. CI is strongly associated in both groups with BPH. PATIENT SUMMARY: In this study, we looked at the prevalence of inflammation and benign prostatic hyperplasia (BPH) on autopsy in Asian and Caucasian men. We found chronic inflammation in>70% of men on autopsy. More chronic inflammation was associated with more BPH.
Authors: Emma H Allott; Sarah C Markt; Lauren E Howard; Adriana C Vidal; Daniel M Moreira; Ramiro Castro-Santamaria; Gerald L Andriole; Lorelei A Mucci; Stephen J Freedland Journal: Cancer Epidemiol Biomarkers Prev Date: 2018-04-18 Impact factor: 4.254
Authors: D M Moreira; D M de O Freitas; J C Nickel; G L Andriole; R Castro-Santamaria; S J Freedland Journal: Prostate Cancer Prostatic Dis Date: 2017-06-06 Impact factor: 5.554
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