Michael L Alosco1, John Gunstad2, Courtney Beard3, Xiaomeng Xu4, Uraina S Clark5, Donald R Labbe6, Beth A Jerskey6, Maura Ladino7, Denise M Cote8, Edward G Walsh9, Athena Poppas10, Ronald A Cohen11, Lawrence H Sweet12. 1. Department of Psychology, Kent State University, Kent, OH, USA malosco@kent.edu. 2. Department of Psychology, Kent State University, Kent, OH, USA. 3. Department of Psychiatry McLean Hospital/Harvard Medical School, Belmont, MA, USA. 4. Department of Psychology, Idaho State University, Pocatello, ID, USA. 5. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 6. Alpert Medical School of Brown University, Department of Psychiatry and Human Behavior, Providence, RI, USA. 7. Columbia Teachers College, New York, NY, USA. 8. Care New England, Providence, RI, USA. 9. Brown University, Departments of Neuroscience and Diagnostic Imaging., Providence, RI, USA. 10. Section of Cardiology, Brown University, Providence, RI USA. 11. Cognitive Aging and Memory Program, Clinical Translational Research Program, Institute on Aging, University of Florida, Gainesville, FL, USA. 12. Alpert Medical School of Brown University, Department of Psychiatry and Human Behavior, Providence, RI, USA Department of Psychology, University of Georgia, Athens, GA, USA.
Abstract
OBJECTIVES: Anxiety is a risk factor for cardiovascular disease (CVD) and is associated with neurocognitive outcomes. The effect of anxiety on brain perfusion in a CVD population has yet to be examined, and no study has investigated the interactive effects of anxiety and cerebral perfusion on cognition. METHODS: A total of 55 older adults with CVD completed the Beck Anxiety Inventory (BAI) and underwent arterial spin labeling to quantify cortical perfusion and thickness. Participants were administered the Mini-Mental State Examination (MMSE) and the Repeatable Battery for the Assessment of Neuropsychological Status. RESULTS: Reduced perfusion predicted poorer cognition and decreased cortical thickness. Higher anxiety score predicted worse memory performance and decreased frontal perfusion. Frontal lobe hypoperfusion combined with increased BAI scores exacerbated poorer MMSE performance. CONCLUSIONS: Higher anxiety may exacerbate the effects of cerebral hypoperfusion on cognitive impairment. Longitudinal studies are needed to confirm our findings and determine whether anxiety treatment improves neurocognitive outcomes in CVD.
OBJECTIVES:Anxiety is a risk factor for cardiovascular disease (CVD) and is associated with neurocognitive outcomes. The effect of anxiety on brain perfusion in a CVD population has yet to be examined, and no study has investigated the interactive effects of anxiety and cerebral perfusion on cognition. METHODS: A total of 55 older adults with CVD completed the Beck Anxiety Inventory (BAI) and underwent arterial spin labeling to quantify cortical perfusion and thickness. Participants were administered the Mini-Mental State Examination (MMSE) and the Repeatable Battery for the Assessment of Neuropsychological Status. RESULTS: Reduced perfusion predicted poorer cognition and decreased cortical thickness. Higher anxiety score predicted worse memory performance and decreased frontal perfusion. Frontal lobe hypoperfusion combined with increased BAI scores exacerbated poorer MMSE performance. CONCLUSIONS: Higher anxiety may exacerbate the effects of cerebral hypoperfusion on cognitive impairment. Longitudinal studies are needed to confirm our findings and determine whether anxiety treatment improves neurocognitive outcomes in CVD.
Authors: Bruce Fischl; David H Salat; Evelina Busa; Marilyn Albert; Megan Dieterich; Christian Haselgrove; Andre van der Kouwe; Ron Killiany; David Kennedy; Shuna Klaveness; Albert Montillo; Nikos Makris; Bruce Rosen; Anders M Dale Journal: Neuron Date: 2002-01-31 Impact factor: 17.173
Authors: Michael L Alosco; Mary Beth Spitznagel; Manfred van Dulmen; Naftali Raz; Ronald Cohen; Lawrence H Sweet; Lisa H Colbert; Richard Josephson; Joel Hughes; Jim Rosneck; John Gunstad Journal: Psychosom Med Date: 2012-10-31 Impact factor: 4.312
Authors: Raymond L C Vogels; Joukje M Oosterman; Barbera van Harten; Alida A Gouw; Jutta M Schroeder-Tanka; Philip Scheltens; Wiesje M van der Flier; Henry C Weinstein Journal: Dement Geriatr Cogn Disord Date: 2007-10-15 Impact factor: 2.959
Authors: P J Wright; O E Mougin; J J Totman; A M Peters; M J Brookes; R Coxon; P E Morris; M Clemence; S T Francis; R W Bowtell; P A Gowland Journal: MAGMA Date: 2008-02-08 Impact factor: 2.310