S Wilson1, B M Hicks2, K T Foster3, M McGue1, W G Iacono1. 1. Department of Psychology,University of Minnesota,Minneapolis, MN,USA. 2. Department of Psychiatry,University of Michigan,Ann Arbor, MI,USA. 3. Departments of Psychiatry and Psychology,University of Michigan,Ann Arbor, MI,USA.
Abstract
BACKGROUND: Major depressive disorder (MDD) that onsets by adolescence is associated with various deficits in psychosocial functioning. However, adolescent-onset MDD often follows a recurrent course that may drive its associated impairment. METHOD: To tease apart these two clinical features, we examined the relative associations of age of onset (adolescent versus adult) and course (recurrent versus single episodes) of MDD with a broad range of psychosocial functioning outcomes assessed in early adulthood. Participants comprised a large, population-based sample of male and female twins from the Minnesota Twin Family Study (MTFS; n = 1252) assessed prospectively from ages 17 to 29 years. RESULTS: A recurrent course of MDD predicted impairment in several psychosocial domains in adulthood, regardless of whether the onset was in adolescence or adulthood. By contrast, adolescent-onset MDD showed less evidence of impairment in adulthood after accounting for recurrence. Individuals with both an adolescent onset and recurrent episodes of MDD represented a particularly severe group with pervasive psychosocial impairment in adulthood. CONCLUSIONS: The negative implications of adolescent-onset MDD for psychosocial functioning in adulthood seem to be due primarily to its frequently recurrent course, rather than its early onset, per se. The results highlight the importance of considering both age of onset and course for understanding MDD and its implications for functioning, and also in guiding targeted intervention efforts.
BACKGROUND: Major depressive disorder (MDD) that onsets by adolescence is associated with various deficits in psychosocial functioning. However, adolescent-onset MDD often follows a recurrent course that may drive its associated impairment. METHOD: To tease apart these two clinical features, we examined the relative associations of age of onset (adolescent versus adult) and course (recurrent versus single episodes) of MDD with a broad range of psychosocial functioning outcomes assessed in early adulthood. Participants comprised a large, population-based sample of male and female twins from the Minnesota Twin Family Study (MTFS; n = 1252) assessed prospectively from ages 17 to 29 years. RESULTS: A recurrent course of MDD predicted impairment in several psychosocial domains in adulthood, regardless of whether the onset was in adolescence or adulthood. By contrast, adolescent-onset MDD showed less evidence of impairment in adulthood after accounting for recurrence. Individuals with both an adolescent onset and recurrent episodes of MDD represented a particularly severe group with pervasive psychosocial impairment in adulthood. CONCLUSIONS: The negative implications of adolescent-onset MDD for psychosocial functioning in adulthood seem to be due primarily to its frequently recurrent course, rather than its early onset, per se. The results highlight the importance of considering both age of onset and course for understanding MDD and its implications for functioning, and also in guiding targeted intervention efforts.
Entities:
Keywords:
Adolescence; age of onset; major depressive disorder; psychosocial functioning; recurrence
Authors: Heather R Bemmels; S Alexandra Burt; Lisa N Legrand; William G Iacono; Matt McGue Journal: Twin Res Hum Genet Date: 2008-06 Impact factor: 1.587
Authors: Ronald C Kessler; Patricia Berglund; Olga Demler; Robert Jin; Kathleen R Merikangas; Ellen E Walters Journal: Arch Gen Psychiatry Date: 2005-06
Authors: D A Solomon; M B Keller; A C Leon; T I Mueller; P W Lavori; M T Shea; W Coryell; M Warshaw; C Turvey; J D Maser; J Endicott Journal: Am J Psychiatry Date: 2000-02 Impact factor: 18.112
Authors: L N Robins; J Wing; H U Wittchen; J E Helzer; T F Babor; J Burke; A Farmer; A Jablenski; R Pickens; D A Regier Journal: Arch Gen Psychiatry Date: 1988-12
Authors: Jennifer Zink; Michele Nicolo; Kellie Imm; Shayan Ebrahimian; Qihan Yu; Kyuwan Lee; Kaylie Zapanta; Jimi Huh; Genevieve F Dunton; Michael I Goran; Kathleen A Page; Christina M Dieli-Conwright; Britni R Belcher Journal: J Psychosom Res Date: 2020-05-15 Impact factor: 3.006
Authors: Paola Gilsanz; Michal Schnaider Beeri; Andrew J Karter; Charles P Quesenberry; Alyce S Adams; Rachel A Whitmer Journal: Aging Ment Health Date: 2018-04-10 Impact factor: 3.658