Literature DB >> 25007725

Combination of intravenous and topical application of tranexamic acid in primary total knee arthroplasty: a prospective randomized controlled trial.

ZeYu Huang1, Jun Ma1, Bin Shen1, FuXing Pei1.   

Abstract

This study was aimed to determine the efficacy and safety of combined intravenous (IV) and topical application of tranexamic acid (TXA) in unilateral total knee arthroplasty (TKA) compared with the IV-TXA. One hundred eight-four patients were enrolled. Participants received either 3g of IV-TXA or 1.5g topical TXA combined with 1.5g IV-TXA. The results revealed that compared with the 3g IV-TXA, adding 1.5g topical TXA to 1.5g IV-TXA in unilateral TKA can have the similar effectiveness in reducing transfusion rate and total blood loss without sacrificing safety. The most important is that by adding topical TXA, patients can gain a smaller maximum decline of hemoglobin (Hb), less drainage volume, less postoperative knee pain, less knee swelling, shorter length of hospital stays and higher short-term satisfaction.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  blood loss; knee swelling; total knee arthroplasty; tranexamic acid; transfusion rate

Mesh：

Substances：

Year:  2014        PMID： 25007725     DOI： 10.1016/j.arth.2014.05.026

Source DB:  PubMed          Journal:  J Arthroplasty        ISSN： 0883-5403            Impact factor:   4.757


  49 in total

1.  Recommendations for the implementation of a Patient Blood Management programme. Application to elective major orthopaedic surgery in adults.

Authors:  Stefania Vaglio; Domenico Prisco; Gianni Biancofiore; Daniela Rafanelli; Paola Antonioli; Michele Lisanti; Lorenzo Andreani; Leonardo Basso; Claudio Velati; Giuliano Grazzini; Giancarlo M Liumbruno
Journal:  Blood Transfus       Date:  2015-12-15       Impact factor: 3.443

2.  Use of tranexamic acid in total knee arthroplasty.

Authors:  Francesco Marra; Federica Rosso; Matteo Bruzzone; Davide Edoardo Bonasia; Federico Dettoni; Roberto Rossi
Journal:  Joints       Date:  2017-02-07

3.  Intra-articular versus intravenous tranexamic acid in primary total knee replacement.

Authors:  Jerry Yongqiang Chen; Shi-Lu Chia; Ngai Nung Lo; Seng Jin Yeo
Journal:  Ann Transl Med       Date:  2015-03

4.  Comparing the efficacy of intravenous or intra-articular tranexamic acid in reducing blood loss in simultaneous bilateral knee replacement surgery without the use of tourniquet.

Authors:  Mridul Arora; Saurabh Singh; Varun Gupta; Ashutosh Dongre; Vijay Shetty
Journal:  Eur J Orthop Surg Traumatol       Date:  2018-03-29

5.  Safety of intravenous tranexamic acid in patients undergoing majororthopaedic surgery: a meta-analysis of randomised controlled trials.

Authors:  Massimo Franchini; Carlo Mengoli; Marco Marietta; Giuseppe Marano; Stefania Vaglio; Simonetta Pupella; Pier Mannuccio Mannucci; Giancarlo M Liumbruno
Journal:  Blood Transfus       Date:  2018-01       Impact factor: 3.443

6.  Is there a role of tranexamic acid in rheumatoid arthritis with total knee arthroplasty? Findings from a multicenter prospective cohort study in China.

Authors:  Wei Huang; Fuxing Pei; Yiting Lei; Jinwei Xie; Qiang Huang
Journal:  Arch Orthop Trauma Surg       Date:  2021-01-01       Impact factor: 3.067

7.  What is the Ideal Route of Administration of Tranexamic Acid in TKA? A Randomized Controlled Trial.

Authors:  Sung Yup Lee; Suri Chong; Dhanasekaraprabu Balasubramanian; Young Gon Na; Tae Kyun Kim
Journal:  Clin Orthop Relat Res       Date:  2017-03-10       Impact factor: 4.176

8.  The efficacy and safety of multiple-dose intravenous tranexamic acid on blood loss following total knee arthroplasty: a randomized controlled trial.

Authors:  Yiting Lei; Jinwei Xie; Bin Xu; Xiaowei Xie; Qiang Huang; Fuxing Pei
Journal:  Int Orthop       Date:  2017-05-31       Impact factor: 3.075

9.  Analysis of a large data set to identify predictors of blood transfusion in primary total hip and knee arthroplasty.

Authors:  ZeYu Huang; Cheng Huang; JinWei Xie; Jun Ma; GuoRui Cao; Qiang Huang; Bin Shen; Virginia Byers Kraus; FuXing Pei
Journal:  Transfusion       Date:  2018-08-25       Impact factor: 3.157

Review 10.  Efficiency and Safety of Intravenous Tranexamic Acid in Simultaneous Bilateral Total Knee Arthroplasty: A Systematic Review and Meta-analysis.

Authors:  Xuan Jiang; Xin-Long Ma; Jian-Xiong Ma
Journal:  Orthop Surg       Date:  2016-08       Impact factor: 2.071
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