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Literature DB >> 25005308

Dynamic disorder and the energetic costs of information transduction.

Abstract

We study a model of dynamic disorder relevant for signal transduction pathways in which enzymatic reaction rates fluctuate over several orders of magnitude. For the simple networks we consider, dynamic disorder drives the system far from equilibrium and imposes an energetic burden for high fidelity signaling capability. We study how the dynamics of the underlying stochastic behavior in the reaction rate process is related to the energetic cost of transmitting information through the network.

Mesh：

Substances：
Enzymes

Year: 2014 PMID： 25005308 PMCID： PMC4106029 DOI： 10.1063/1.4885725

Source DB: PubMed Journal: J Chem Phys ISSN： 0021-9606 Impact factor: 3.488

19 in total

Review 1. Illuminating single molecules in condensed matter.

Authors: W E Moerner; M Orrit
Journal: Science Date: 1999-03-12 Impact factor: 47.728

2. Stretched exponential decay and correlations in the catalytic activity of fluctuating single lipase molecules.

Authors: Ophir Flomenbom; Kelly Velonia; Davey Loos; Sadahiro Masuo; Mircea Cotlet; Yves Engelborghs; Johan Hofkens; Alan E Rowan; Roeland J M Nolte; Mark Van der Auweraer; Frans C de Schryver; Joseph Klafter
Journal: Proc Natl Acad Sci U S A Date: 2005-02-04 Impact factor: 11.205

Dynamic disorder and the energetic costs of information transduction.

Review 1. Illuminating single molecules in condensed matter.

2. Stretched exponential decay and correlations in the catalytic activity of fluctuating single lipase molecules.

3. Using independent open-to-closed transitions to simplify aggregated Markov models of ion channel gating kinetics.

Review 4. Fluctuating enzymes: lessons from single-molecule studies.

5. A modified next reaction method for simulating chemical systems with time dependent propensities and delays.

Review 6. Network motifs: theory and experimental approaches.

7. Theory of the energy transfer efficiency and fluorescence lifetime distribution in single-molecule FRET.

8. Generic schemes for single-molecule kinetics. 1: Self-consistent pathway solutions for renewal processes.

9. Maximum likelihood estimation of aggregated Markov processes.

10. Single-molecule kinetics of lambda exonuclease reveal base dependence and dynamic disorder.

1. Transitions in genetic toggle switches driven by dynamic disorder in rate coefficients.