Breno Q Farah1, Raphael M Ritti-Dias, Gabriel G Cucato, Annelise L Menêses, Andrew W Gardner. 1. 1Graduate Program in Physical Education, Pernambuco University, Pernambuco, BRAZIL; 2Albert Einstein Hospital, São Paulo, BRAZIL; and 3Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Abstract
PURPOSE: Ventilatory threshold (VT) is considered a clinically important marker of cardiovascular function in several populations, including patients with claudication, because it is related to walking capacity and hemodynamics. The purpose of this study was to identify clinical predictors for VT achievement in patients with intermittent claudication. METHODS: One hundred and seventy-seven (n = 177) patients with intermittent claudication performed a progressive graded cardiopulmonary treadmill test until maximal claudication pain. Oxygen uptake (V˙O2) was continuously measured during the test, and afterwards, VT was visually detected. Clinical characteristics, demographic data, comorbid conditions, and cardiovascular risk factors were obtained. Patients who achieved and did not achieve VT were compared, as well as the workload that VT occurred in the former group. RESULTS: VT was achieved in 134 patients (76%), and the mean V˙O2 at VT for these patients was 10.8 ± 2.4 mL·kg(-1)·min(-1). Patients who did not achieve VT presented lower ankle brachial index (ABI), claudication onset time, peak walking time, and V˙O2peak, and the proportion of women was higher compared with patients who achieved VT (P < 0.05). Multiple linear regression analysis identified that sex (b = 0.25, P = 0.002), body mass index (b = -0.18, P = 0.025), peak walking time (b = 0.17, P = 0.044), and ABI (b = 0.23, P = 0.006) were predictors of V˙O2 at VT. CONCLUSIONS: Forty-three patients (24%) with intermittent claudication did not achieve VT, and these patients were mostly women and those with greater severity of disease. Moreover, in those who reached VT, the predictors of poor VT were female sex, high body mass index, low peak walking time, and low ABI.
PURPOSE: Ventilatory threshold (VT) is considered a clinically important marker of cardiovascular function in several populations, including patients with claudication, because it is related to walking capacity and hemodynamics. The purpose of this study was to identify clinical predictors for VT achievement in patients with intermittent claudication. METHODS: One hundred and seventy-seven (n = 177) patients with intermittent claudication performed a progressive graded cardiopulmonary treadmill test until maximal claudication pain. Oxygen uptake (V˙O2) was continuously measured during the test, and afterwards, VT was visually detected. Clinical characteristics, demographic data, comorbid conditions, and cardiovascular risk factors were obtained. Patients who achieved and did not achieve VT were compared, as well as the workload that VT occurred in the former group. RESULTS:VT was achieved in 134 patients (76%), and the mean V˙O2 at VT for these patients was 10.8 ± 2.4 mL·kg(-1)·min(-1). Patients who did not achieve VT presented lower ankle brachial index (ABI), claudication onset time, peak walking time, and V˙O2peak, and the proportion of women was higher compared with patients who achieved VT (P < 0.05). Multiple linear regression analysis identified that sex (b = 0.25, P = 0.002), body mass index (b = -0.18, P = 0.025), peak walking time (b = 0.17, P = 0.044), and ABI (b = 0.23, P = 0.006) were predictors of V˙O2 at VT. CONCLUSIONS: Forty-three patients (24%) with intermittent claudication did not achieve VT, and these patients were mostly women and those with greater severity of disease. Moreover, in those who reached VT, the predictors of poor VT were female sex, high body mass index, low peak walking time, and low ABI.
Authors: Gary J Balady; Ross Arena; Kathy Sietsema; Jonathan Myers; Lola Coke; Gerald F Fletcher; Daniel Forman; Barry Franklin; Marco Guazzi; Martha Gulati; Steven J Keteyian; Carl J Lavie; Richard Macko; Donna Mancini; Richard V Milani Journal: Circulation Date: 2010-06-28 Impact factor: 29.690
Authors: John E Hall; Alexandre A da Silva; Jussara M do Carmo; John Dubinion; Shereen Hamza; Shankar Munusamy; Grant Smith; David E Stec Journal: J Biol Chem Date: 2010-03-26 Impact factor: 5.157
Authors: M da Rocha Chehuen; G Cucato; J Dos Anjos Souza Barbosa; L Costa; R Ritti-Dias; N Wolosker; C de Moraes Forjaz Journal: Vasa Date: 2012-07 Impact factor: 1.961
Authors: Jacilene Guedes da Oliveira; João Paulo dos Anjos Souza Barbosa; Breno Quintella Farah; Marcel da Rocha Chehuen; Gabriel Grizzo Cucato; Nelson Wolosker; Cláudia Lúcia de Moraes Forjaz; Raphael Mendes Ritti Dias Journal: Einstein (Sao Paulo) Date: 2012 Oct-Dec
Authors: Raphael Mendes Ritti-Dias; Cláudia Lúcia de Moraes Forjaz; Gabriel Grizzo Cucato; Luis Augusto Riani Costa; Nelson Wolosker; Maria de Fátima Nunes Marucci Journal: J Cardiopulm Rehabil Prev Date: 2009 Nov-Dec Impact factor: 2.081
Authors: Nicholas J Leeper; Jonathan Myers; Margaret Zhou; Kevin T Nead; Arshiya Syed; Yoko Kojima; Roxanne Diaz Caceres; John P Cooke Journal: J Vasc Surg Date: 2012-10-06 Impact factor: 4.268
Authors: Alex D Martini; Lance C Dalleck; Gaizka Mejuto; Trent Larwood; Ryan M Weatherwax; Joyce S Ramos Journal: Int J Environ Res Public Health Date: 2022-03-26 Impact factor: 3.390