| Literature DB >> 25000283 |
Lehao Huang1, Xudong Sun, Qian Li, Chenze Qi.
Abstract
A Pd-catalyzed regioselective alkylation of C8-H bonds in 1-naphthylamides containing a quinolinamide or picolinamide moiety as a bidentate directing group with alkyl halides is reported. The amide directing group can be easily hydrolyzed under basic conditions. Various alkyl halides including alkyl iodides and benzyl bromide or chloride can be employed as coupling partners, exclusively providing 8-alkyl-1-naphthylamide derivatives.Entities:
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Year: 2014 PMID： 25000283 DOI： 10.1021/jo500932x
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354