Literature DB >> 24999609

Highly enantioselective aza-Henry reaction with isatin N-Boc ketimines.

Melireth Holmquist1, Gonzalo Blay, José R Pedro.   

Abstract

A highly enantioselective aza-Henry reaction with isatin N-Boc ketimines using a Cu(II)-BOX complex as a catalyst is described. The reaction, which does not require protection of the N1 atom, provides the corresponding nitroamines bearing a quaternary stereocentre with high yields and enantiomeric excesses (up to 99.9%).

Entities:  

Year:  2014        PMID： 24999609     DOI： 10.1039/c4cc04051a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

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Authors:  Chung Whan Lee; Seo-Jung Han; Scott C Virgil; Brian M Stoltz
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3.  Effects of solvents on the DACBO-catalyzed vinylogous Henry reaction of isatin with 3,5-dimethyl-4-nitroisoxazole "on-water" and in solution from QM/MM MC simulations.

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4.  Guanidine-Amide-Catalyzed Aza-Henry Reaction of Isatin-Derived Ketimines: Origin of Selectivity and New Catalyst Design.

Authors:  Jiajia He; Dianyong Tang; Changwei Hu; Zhishan Su
Journal:  Molecules       Date:  2021-03-31       Impact factor: 4.411
  4 in total

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