Literature DB >> 2499297

Valpromide is a poor inhibitor of the cytosolic epoxide hydrolase.

G M Pacifici1, A Temellini, L Giuliani, A Rane, H Thomas, F Oesch.   

Abstract

The effect of the antiepileptics valpromide and sodium valproate on the cytosolic epoxide hydrolase was studied in human fetal liver, kidneys and adrenals and from human adult liver and kidneys. Trans-stilbene oxide was used as substrate. Valpromide (10 mM) lowered the activity of the epoxide hydrolase to one half of the control in all organs studied. Sodium valproate (10 mM) was less powerful as an inhibitor than valpromide; however, it exerted a significant inhibition in all tissues studied.

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Year:  1989        PMID： 2499297     DOI： 10.1007/bf00316440

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  17 in total

1.  Valpromide inhibits human epoxide hydrolase.

Authors:  G M Pacifici; M Franchi; C Bencini; A Rane
Journal:  Br J Clin Pharmacol       Date:  1986-09       Impact factor: 4.335

2.  Valpromide but not sodium hydrogen divalproate inhibits epoxide hydrolase in human liver.

Authors:  G M Pacifici; A Rane
Journal:  Pharmacol Toxicol       Date:  1987-03

3.  A study on the metabolism of dipropylacetamide to dipropylacetic acid in rats.

Authors:  F Pisani; A Fazio; G Oteri; R Di Perri
Journal:  J Pharm Pharmacol       Date:  1982-01       Impact factor: 3.765

4.  Concomitant induction of cytosolic but not microsomal epoxide hydrolase with peroxisomal beta-oxidation by various hypolipidemic compounds.

Authors:  L Schladt; R Hartmann; C Timms; M Strolin-Benedetti; P Dostert; W Wörner; F Oesch
Journal:  Biochem Pharmacol       Date:  1987-02-01       Impact factor: 5.858

5.  Valpromide/carbamazepine and risk of teratogenicity.

Authors:  G M Pacifici; T Tomson; L Bertilsson; A Rane
Journal:  Lancet       Date:  1985-02-16       Impact factor: 79.321

6.  Cytosolic and microsomal epoxide hydrolases: differential properties in mammalian liver.

Authors:  K Ota; B D Hammock
Journal:  Science       Date:  1980-03-28       Impact factor: 47.728

7.  Distribution and properties of a mammalian soluble epoxide hydrase.

Authors:  S S Gill; B D Hammock
Journal:  Biochem Pharmacol       Date:  1980-02       Impact factor: 5.858

8.  Interindividual variations in the activities of cytosolic and microsomal epoxide hydrolase in human liver.

Authors:  I Mertes; R Fleischmann; H R Glatt; F Oesch
Journal:  Carcinogenesis       Date:  1985-02       Impact factor: 4.944

9.  Cytosolic epoxide hydrolase in humans: development and tissue distribution.

Authors:  G M Pacifici; A Temellini; L Giuliani; A Rane; H Thomas; F Oesch
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

10.  Cytosolic and microsomal epoxide hydrolases are immunologically distinguishable from each other in the rat and mouse.

Authors:  T M Guenthner; B D Hammock; U Vogel; F Oesch
Journal:  J Biol Chem       Date:  1981-04-10       Impact factor: 5.157
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