Literature DB >> 24988458

SnapShot: sirtuins, NAD, and aging.

Takashi Nakagawa1, Leonard Guarente2.   

Abstract

Sirtuins are highly conserved nicotinamide adenine dinucleotide (NAD)-dependent enzymes that regulate a wide range of biological processes, including aging, in several species. This SnapShot provides a comprehensive overview of the targets, enzymatic activities, and physiological functions of the seven mammalian sirtuins, as well as the regulation of the biosynthetic pathways regulating NAD availability.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 24988458     DOI： 10.1016/j.cmet.2014.06.001

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  21 in total

1.  SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway.

Authors:  Claudia C S Chini; Jair M Espindola-Netto; Gourish Mondal; Anatilde M Gonzalez Guerrico; Veronica Nin; Carlos Escande; Mauro Sola-Penna; Jin-San Zhang; Daniel D Billadeau; Eduardo N Chini
Journal:  Clin Cancer Res       Date:  2015-12-11       Impact factor: 12.531

Review 2.  Sirtuins and FoxOs in osteoporosis and osteoarthritis.

Authors:  Maria Almeida; Ryan M Porter
Journal:  Bone       Date:  2019-02-06       Impact factor: 4.398

3.  Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling.

Authors:  Nannan Zhang; Zhongchi Li; Wei Mu; Liyuan Li; Yaru Liang; Maoyang Lu; Zhuoran Wang; Ying Qiu; Zhao Wang
Journal:  Cell Cycle       Date:  2016       Impact factor: 4.534

Review 4.  Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle.

Authors:  Ignacio Navas-Enamorado; Michel Bernier; Gloria Brea-Calvo; Rafael de Cabo
Journal:  Ageing Res Rev       Date:  2017-05-06       Impact factor: 10.895

Review 5.  Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds.

Authors:  Michael S Bonkowski; David A Sinclair
Journal:  Nat Rev Mol Cell Biol       Date:  2016-08-24       Impact factor: 94.444

Review 6.  The NAD+-Dependent Family of Sirtuins in Cerebral Ischemia and Preconditioning.

Authors:  Nathalie Khoury; Kevin B Koronowski; Juan I Young; Miguel A Perez-Pinzon
Journal:  Antioxid Redox Signal       Date:  2017-08-07       Impact factor: 8.401

7.  Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.

Authors:  Frank K Huynh; Xiaoke Hu; Zhihong Lin; James D Johnson; Matthew D Hirschey
Journal:  J Inherit Metab Dis       Date:  2017-07-19       Impact factor: 4.982

Review 8.  Sirtuins and Accelerated Aging in Scleroderma.

Authors:  Anne E Wyman; Sergei P Atamas
Journal:  Curr Rheumatol Rep       Date:  2018-03-17       Impact factor: 4.592

9.  Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy.

Authors:  Guoxiang Liu; Seong-Hoon Park; Marta Imbesi; William Joseph Nathan; Xianghui Zou; Yueming Zhu; Haiyan Jiang; Loukia Parisiadou; David Gius
Journal:  Antioxid Redox Signal       Date:  2016-09-08       Impact factor: 8.401

10.  Sirt1 in cerebral ischemia.

Authors:  Kevin B Koronowski; Miguel A Perez-Pinzon
Journal:  Brain Circ       Date:  2015-09-30
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