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Literature DB >> 27552971

Slowing ageing by design: the rise of NAD⁺ and sirtuin-activating compounds.

Michael S Bonkowski¹, David A Sinclair^1,2.

Abstract

The sirtuins (SIRT1-7) are a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of ageing. Mice engineered to express additional copies of SIRT1 or SIRT6, or treated with sirtuin-activating compounds (STACs) such as resveratrol and SRT2104 or with NAD+ precursors, have improved organ function, physical endurance, disease resistance and longevity. Trials in non-human primates and in humans have indicated that STACs may be safe and effective in treating inflammatory and metabolic disorders, among others. These advances have demonstrated that it is possible to rationally design molecules that can alleviate multiple diseases and possibly extend lifespan in humans.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

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Year: 2016 PMID： 27552971 PMCID： PMC5107309 DOI： 10.1038/nrm.2016.93

Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444

200 in total

1. Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose.

Authors: K G Tanner; J Landry; R Sternglanz; J M Denu
Journal: Proc Natl Acad Sci U S A Date: 2000-12-19 Impact factor: 11.205

2. Does diet or alcohol explain the French paradox.

Authors: G P Walsh
Journal: Lancet Date: 1995-02-25 Impact factor: 79.321

3. Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss.

Authors: Kevin D Brown; Sadia Maqsood; Jing-Yi Huang; Yong Pan; William Harkcom; Wei Li; Anthony Sauve; Eric Verdin; Samie R Jaffrey
Journal: Cell Metab Date: 2014-12-02 Impact factor: 27.287

4. The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs.

Authors: Fiorella Ghisays; Cynthia S Brace; Shawn M Yackly; Hyock Joo Kwon; Kathryn F Mills; Elena Kashentseva; Igor P Dmitriev; David T Curiel; Shin-Ichiro Imai; Tom Ellenberger
Journal: Cell Rep Date: 2015-03-12 Impact factor: 9.423

5. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus.

Authors: Jayesh Kumar Bhatt; Sabin Thomas; Moola Joghee Nanjan
Journal: Nutr Res Date: 2012-07-27 Impact factor: 3.315

6. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Authors: Konrad T Howitz; Kevin J Bitterman; Haim Y Cohen; Dudley W Lamming; Siva Lavu; Jason G Wood; Robert E Zipkin; Phuong Chung; Anne Kisielewski; Li-Li Zhang; Brandy Scherer; David A Sinclair
Journal: Nature Date: 2003-08-24 Impact factor: 49.962

7. Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases.

Authors: Margie T Borra; Michael R Langer; James T Slama; John M Denu
Journal: Biochemistry Date: 2004-08-03 Impact factor: 3.162

8. Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models.

Authors: Bing Gong; Yong Pan; Prashant Vempati; Wei Zhao; Lindsay Knable; Lap Ho; Jun Wang; Magdalena Sastre; Kenjiro Ono; Anthony A Sauve; Giulio M Pasinetti
Journal: Neurobiol Aging Date: 2013-01-09 Impact factor: 4.673

9. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

Authors: Daniel Kraus; Qin Yang; Dong Kong; Alexander S Banks; Lin Zhang; Joseph T Rodgers; Eija Pirinen; Thomas C Pulinilkunnil; Fengying Gong; Ya-chin Wang; Yana Cen; Anthony A Sauve; John M Asara; Odile D Peroni; Brett P Monia; Sanjay Bhanot; Leena Alhonen; Pere Puigserver; Barbara B Kahn
Journal: Nature Date: 2014-04-10 Impact factor: 49.962

10. A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers.

Authors: Vincenzo Libri; Andrew P Brown; Giulio Gambarota; Jonathan Haddad; Gregory S Shields; Helen Dawes; David J Pinato; Ethan Hoffman; Peter J Elliot; George P Vlasuk; Eric Jacobson; Martin R Wilkins; Paul M Matthews
Journal: PLoS One Date: 2012-12-20 Impact factor: 3.240

233 in total

Slowing ageing by design: the rise of NAD⁺ and sirtuin-activating compounds.

1. Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose.

2. Does diet or alcohol explain the French paradox.

3. Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss.

4. The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs.

5. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus.

6. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

7. Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases.

8. Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models.

9. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

10. A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers.

Review 1. Key proteins and pathways that regulate lifespan.

2. The Quest for Osteoporosis Mechanisms and Rational Therapies: How Far We've Come, How Much Further We Need to Go.

Review 3. Metabolic pathways at the crossroads of diabetes and inborn errors.

4. Senolytics: The Modern Snake Oil?

Review 5. Antiaging Therapies, Cognitive Impairment, and Dementia.

6. Calorie restriction breaks an epigenetic barrier to longevity.

Review 7. The Spectrum of Fundamental Basic Science Discoveries Contributing to Organismal Aging.

Review 8. Sirtuins and NAD⁺ in the Development and Treatment of Metabolic and Cardiovascular Diseases.

Review 9. NAD⁺ and sirtuins in retinal degenerative diseases: A look at future therapies.

Review 10. Could Sirtuin Activities Modify ALS Onset and Progression?