Literature DB >> 24988457

Mitobolites: the elixir of life.

Subhash D Katewa1, Amit Khanna1, Pankaj Kapahi2.   

Abstract

One of the biggest challenges in biology is to understand how mitochondria influence aging and age-related diseases. Chin et al. (2014) reveal how a mitochondrial metabolite (mitobolite) inhibits mitochondrial ATPase and extends lifespan by mimicking dietary restriction in worms.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 24988457      PMCID： PMC4103626          DOI： 10.1016/j.cmet.2014.06.013

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  11 in total

Review 1.  Metabolism, ubiquinone synthesis, and longevity.

Authors:  Hugo Aguilaniu; Jenni Durieux; Andrew Dillin
Journal:  Genes Dev       Date:  2005-10-15       Impact factor: 11.361

Review 2.  Mitochondria--a nexus for aging, calorie restriction, and sirtuins?

Authors:  Leonard Guarente
Journal:  Cell       Date:  2008-01-25       Impact factor: 41.582

3.  Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans.

Authors:  Laurent Mouchiroud; Laurent Molin; Prasad Kasturi; Mohamed N Triba; Marc Emmanuel Dumas; Marieangela C Wilson; Andrew P Halestrap; Damien Roussel; Ingrid Masse; Nicolas Dallière; Laurent Ségalat; Marc Billaud; Florence Solari
Journal:  Aging Cell       Date:  2010-11-15       Impact factor: 9.304

4.  Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism.

Authors:  Jeffrey A Butler; Natascia Ventura; Thomas E Johnson; Shane L Rea
Journal:  FASEB J       Date:  2010-08-23       Impact factor: 5.191

Review 5.  With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging.

Authors:  Pankaj Kapahi; Di Chen; Aric N Rogers; Subhash D Katewa; Patrick Wai-Lun Li; Emma L Thomas; Lutz Kockel
Journal:  Cell Metab       Date:  2010-06-09       Impact factor: 27.287

6.  PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.

Authors:  Siler H Panowski; Suzanne Wolff; Hugo Aguilaniu; Jenni Durieux; Andrew Dillin
Journal:  Nature       Date:  2007-05-02       Impact factor: 49.962

7.  Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway.

Authors:  David S Williams; Alan Cash; Lara Hamadani; Tanja Diemer
Journal:  Aging Cell       Date:  2009-09-30       Impact factor: 9.304

8.  A metabolic signature for long life in the Caenorhabditis elegans Mit mutants.

Authors:  Jeffrey A Butler; Robert J Mishur; Shylesh Bhaskaran; Shane L Rea
Journal:  Aging Cell       Date:  2013-02       Impact factor: 9.304

9.  4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila.

Authors:  Brian M Zid; Aric N Rogers; Subhash D Katewa; Misha A Vargas; Marysia C Kolipinski; Tony Au Lu; Seymour Benzer; Pankaj Kapahi
Journal:  Cell       Date:  2009-10-02       Impact factor: 41.582

Review 10.  Mitochondria as signaling organelles.

Authors:  Navdeep S Chandel
Journal:  BMC Biol       Date:  2014-05-27       Impact factor: 7.431
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  4 in total

Review 1.  History and progress of hypotheses and clinical trials for Alzheimer's disease.

Authors:  Pei-Pei Liu; Yi Xie; Xiao-Yan Meng; Jian-Sheng Kang
Journal:  Signal Transduct Target Ther       Date:  2019-08-23

Review 2.  Mechanisms Through Which Some Mitochondria-Generated Metabolites Act as Second Messengers That Are Essential Contributors to the Aging Process in Eukaryotes Across Phyla.

Authors:  Paméla Dakik; Younes Medkour; Karamat Mohammad; Vladimir I Titorenko
Journal:  Front Physiol       Date:  2019-04-18       Impact factor: 4.566

3.  Mitochondrial fragmentation enables localized signaling required for cell repair.

Authors:  Adam Horn; Shreya Raavicharla; Sonna Shah; Dan Cox; Jyoti K Jaiswal
Journal:  J Cell Biol       Date:  2020-05-04       Impact factor: 10.539

4.  Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans.

Authors:  Esmaeil Dehghan; Mohammad Goodarzi; Bahar Saremi; Rueyling Lin; Hamid Mirzaei
Journal:  Nat Commun       Date:  2019-10-28       Impact factor: 14.919
  4 in total

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