| Literature DB >> 24985330 |
Pirjo M Apaja1, Gergely L Lukacs2.
Abstract
The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets conformationally damaged membrane proteins for lysosomal/vacuolar degradation. Here, we provide an overview of emerging aspects of the underlying mechanisms of PM QC that fulfill a critical role in preserving cellular protein homeostasis in health and diseases. ©2014 Int. Union Physiol. Sci./Am. Physiol. Soc.Mesh:
Substances:
Year: 2014 PMID: 24985330 PMCID: PMC4103059 DOI: 10.1152/physiol.00058.2013
Source DB: PubMed Journal: Physiology (Bethesda) ISSN: 1548-9221