C Montagnese1, T Nutile2, A A Marphatia3, C S Grijalva-Eternod4, M Siervo5, M Ciullo6, J C Wells7. 1. Childhood Nutrition Research Centre, UCL Institute of Child Health, London, UK; Institute of Genetics and Biophysics, "A. Buzzati-Traverso" CNR, Napoli, Italy. 2. Institute of Genetics and Biophysics, "A. Buzzati-Traverso" CNR, Napoli, Italy. 3. Department of Geography, University of Cambridge, UK. 4. UCL Institute for Global Health, London, UK. 5. Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, UK. 6. Institute of Genetics and Biophysics, "A. Buzzati-Traverso" CNR, Napoli, Italy. Electronic address: ciullo@igb.cnr.it. 7. Childhood Nutrition Research Centre, UCL Institute of Child Health, London, UK.
Abstract
BACKGROUND AND AIMS: Whereas adult weight or body mass index (BMI) are directly associated with blood pressure (BP), birth weight is inversely associated with BP. The scenario for height is more complex, as both tall and short stature have been associated with higher BP. We used a theoretical model treating sitting height (SH) and tissue masses (fat mass, lean mass) as components of metabolic load, and leg length (LL) as a marker of homeostatic metabolic capacity. We predicted that decreased capacity and increased load would be independently associated with increased BP.. METHODS AND RESULTS: Anthropometry, body composition (bio-electrical impedance analysis) and BP were measured in 601 adults (228 male) aged 20-91 years from three hill villages in southern Italy. Multiple regression analysis was used to investigate associations of body composition and anthropometry with BP. Adjusting for age, systolic BP (SBP) was associated with lean mass in males, and with adiposity in females, whereas diastolic BP (DBP) was associated with fat mass in both sexes. Associations of LL and SH with BP were in opposite directions. LL was inversely associated with SBP and DBP in males, with a similar trend evident in females. SH was directly associated with SBP and DBP in females, and with DBP in males. CONCLUSIONS: Consistent with our theoretical model, metabolic load is associated with increased BP, though differently between the sexes, whereas metabolic capacity is independently associated with lower BP. Our findings suggest that early growth improves hemodynamic tolerance of high metabolic load in adulthood..
BACKGROUND AND AIMS: Whereas adult weight or body mass index (BMI) are directly associated with blood pressure (BP), birth weight is inversely associated with BP. The scenario for height is more complex, as both tall and short stature have been associated with higher BP. We used a theoretical model treating sitting height (SH) and tissue masses (fat mass, lean mass) as components of metabolic load, and leg length (LL) as a marker of homeostatic metabolic capacity. We predicted that decreased capacity and increased load would be independently associated with increased BP.. METHODS AND RESULTS: Anthropometry, body composition (bio-electrical impedance analysis) and BP were measured in 601 adults (228 male) aged 20-91 years from three hill villages in southern Italy. Multiple regression analysis was used to investigate associations of body composition and anthropometry with BP. Adjusting for age, systolic BP (SBP) was associated with lean mass in males, and with adiposity in females, whereas diastolic BP (DBP) was associated with fat mass in both sexes. Associations of LL and SH with BP were in opposite directions. LL was inversely associated with SBP and DBP in males, with a similar trend evident in females. SH was directly associated with SBP and DBP in females, and with DBP in males. CONCLUSIONS: Consistent with our theoretical model, metabolic load is associated with increased BP, though differently between the sexes, whereas metabolic capacity is independently associated with lower BP. Our findings suggest that early growth improves hemodynamic tolerance of high metabolic load in adulthood..
Authors: Natasha Lelijveld; Andrew Seal; Jonathan C Wells; Jane Kirkby; Charles Opondo; Emmanuel Chimwezi; James Bunn; Robert Bandsma; Robert S Heyderman; Moffat J Nyirenda; Marko Kerac Journal: Lancet Glob Health Date: 2016-07-25 Impact factor: 26.763
Authors: Jonathan C K Wells; Delan Devakumar; Dharma S Manandhar; Naomi Saville; S S Chaube; A Costello; David Osrin Journal: Eur J Clin Nutr Date: 2018-08-28 Impact factor: 4.016