Literature DB >> 2498244

Potentiation of invasive capacity of rat ascites hepatoma cells by transforming growth factor-beta.

M Mukai1, K Shinkai, K Komatsu, H Akedo.   

Abstract

The in vitro invasive capacity of poorly invasive cells (W1), which were cloned from rat ascites hepatoma cells (AH 130), was potentiated dose- and time-dependently by pretreating the cells with transforming growth factor-beta (TGF-beta). This potentiation of invasive capacity was completely abolished by anti-TGF-beta antibody. When the treated cells were ip inoculated into rats, the cells extensively invaded the peritoneum, and formed penetrating tumor nodules. The effect of TGF-beta was reversed by subculturing the treated cells without TGF-beta. The potentiation of invasive capacity by TGF-beta might participate in platelet-associated enhancement of tumor cell metastasis.

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Year:  1989        PMID： 2498244      PMCID： PMC5917692          DOI： 10.1111/j.1349-7006.1989.tb02275.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  14 in total

1.  Macrophage potentiation of invasive capacity of rat ascites hepatoma cells.

Authors:  M Mukai; K Shinkai; R Tateishi; Y Mori; H Akedo
Journal:  Cancer Res       Date:  1987-04-15       Impact factor: 12.701

2.  Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

Authors:  A B Roberts; M B Sporn; R K Assoian; J M Smith; N S Roche; L M Wakefield; U I Heine; L A Liotta; V Falanga; J H Kehrl
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

3.  Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta.

Authors:  T A Mustoe; G F Pierce; A Thomason; P Gramates; M B Sporn; T F Deuel
Journal:  Science       Date:  1987-09-11       Impact factor: 47.728

4.  The TGF-beta family of growth and differentiation factors.

Authors:  J Massagué
Journal:  Cell       Date:  1987-05-22       Impact factor: 41.582

5.  Functional role of platelets in experimental metastasis studied with cloned murine fibrosarcoma cell variants.

Authors:  M Mahalingam; K E Ugen; K J Kao; P A Klein
Journal:  Cancer Res       Date:  1988-03-15       Impact factor: 12.701

6.  Superoxide radical potentiates invasive capacity of rat ascites hepatoma cells in vitro.

Authors:  K Shinkai; M Mukai; H Akedo
Journal:  Cancer Lett       Date:  1986-07       Impact factor: 8.679

7.  Factor from rat liver with antiinvasive potential on rat ascites hepatoma cells.

Authors:  K Shinkai; M Mukai; K Komatsu; H Akedo
Journal:  Cancer Res       Date:  1988-07-01       Impact factor: 12.701

8.  Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

Authors:  R K Assoian; A Komoriya; C A Meyers; D M Miller; M B Sporn
Journal:  J Biol Chem       Date:  1983-06-10       Impact factor: 5.157

Review 9.  Role of platelets in tumor cell metastases.

Authors:  S Karpatkin; E Pearlstein
Journal:  Ann Intern Med       Date:  1981-11       Impact factor: 25.391

10.  Inhibition of spontaneous and experimental tumor metastasis by the calcium antagonist verapamil.

Authors:  T Tsuruo; H Iida; F Makishima; T Yamori; H Kawabata; S Tsukagoshi; Y Sakurai
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333
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  17 in total

1.  Down-regulation of focal adhesion kinase, pp125FAK, in endothelial cell retraction during tumor cell invasion.

Authors:  H Okamoto; S Nakamori; M Mukai; K Shinkai; H Ohigashi; O Ishikawa; H Furukawa; S Imaoka; Y Matumoto; M Monden; H Akedo
Journal:  Clin Exp Metastasis       Date:  1998-04       Impact factor: 5.150

2.  Decreased expression of LMO7 and its clinicopathological significance in human lung adenocarcinoma.

Authors:  Hiroyuki Nakamura; Keiko Hori; Miki Tanaka-Okamoto; Masahiko Higashiyama; Yu Itoh; Masahiro Inoue; Setsuko Morinaka; Jun Miyoshi
Journal:  Exp Ther Med       Date:  2011-08-11       Impact factor: 2.447

3.  Soluble factors released by the target organ enhance the urokinase-type plasminogen activator activity of metastatic tumor cells.

Authors:  E Bal de Kier Joffé; D F Alonso; L Puricelli
Journal:  Clin Exp Metastasis       Date:  1991 Jan-Feb       Impact factor: 5.150

4.  Involvement of small GTPases Rho and Rac in the invasion of rat ascites hepatoma cells.

Authors:  F Imamura; M Mukai; M Ayaki; K Takemura; T Horai; K Shinkai; H Nakamura; H Akedo
Journal:  Clin Exp Metastasis       Date:  1999-03       Impact factor: 5.150

5.  Transforming growth factor-beta synthesis by human peritoneal mesothelial cells. Induction by interleukin-1.

Authors:  F A Offner; H Feichtinger; S Stadlmann; P Obrist; C Marth; P Klingler; B Grage; M Schmahl; C Knabbe
Journal:  Am J Pathol       Date:  1996-05       Impact factor: 4.307

6.  Interaction of human malignant melanoma (ST-ML-12) tumor spheroids with endothelial cell monolayers. Damage to endothelium by oxygen-derived free radicals.

Authors:  F A Offner; H C Wirtz; J Schiefer; I Bigalke; B Klosterhalfen; F Bittinger; C Mittermayer; C J Kirkpatrick
Journal:  Am J Pathol       Date:  1992-09       Impact factor: 4.307

7.  Enhanced paracellular barrier function of rat mesothelial cells partially protects against cancer cell penetration.

Authors:  H Tobioka; N Sawada; Y Zhong; M Mori
Journal:  Br J Cancer       Date:  1996-08       Impact factor: 7.640

8.  Differential responses of scirrhous and well-differentiated gastric cancer cells to orthotopic fibroblasts.

Authors:  M Yashiro; Y S Chung; T Kubo; F Hato; M Sowa
Journal:  Br J Cancer       Date:  1996-10       Impact factor: 7.640

9.  Establishment of two new scirrhous gastric cancer cell lines: analysis of factors associated with disseminated metastasis.

Authors:  M Yashiro; Y S Chung; S Nishimura; T Inoue; M Sowa
Journal:  Br J Cancer       Date:  1995-11       Impact factor: 7.640

10.  Inhibition of in vitro tumor cell invasion by transmethylation inhibitors.

Authors:  K Shinkai; M Mukai; T Horai; H Ohigashi; S Nishikawa; H Inoue; Y Takeda; H Akedo
Journal:  Jpn J Cancer Res       Date:  1989-08
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