Young Wan Kim1, Soo-Ki Kim2, Cheol Su Kim2, Ik Yong Kim1, Mee Yon Cho3, Nam Kyu Kim4. 1. Department of Surgery, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea. 2. Department of Microbiology, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea. 3. Department of Pathology, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea. 4. Department of Surgery, College of Medicine, Yonsei University, Seoul, Republic of Korea namkyuk@yuhs.ac.
Abstract
BACKGROUND: We examined cytokine profiles and evaluated the association between cytokine levels, pathological stages, and neutrophil/lymphocyte ratio (NLR). MATERIALS AND METHODS: Patients with colorectal cancer (n=20, TNM stage I, II, and III) were enrolled. Levels of nine cytokines [interleukin (IL)-4,-6, -8, -10, -12, tumor necrosis factor-alpha (TNF-α), granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon-gamma (IFN-γ), and vascular endothelial growth factor (VEGF)] were measured in serum, normal mucosa, and tumor using the Bio-Plex® cytokine assay. RESULTS: The mean IL8, GM-CSF and VEGF levels were higher in tumors, whereas the mean IL6 level was higher in serum. Cytokine levels correlated with TNM stage (IL6 and IL8 in serum, and IL8 and VEGF in tumor) and with NLR (IL6 and IL8 in serum, and IL8 in tumor). CONCLUSION: Different cytokine profiles were observed in serum, normal mucosa, and tumor tissue. The elevation of specific cytokines in sera or tumors reflects features of advanced disease. Copyright
BACKGROUND: We examined cytokine profiles and evaluated the association between cytokine levels, pathological stages, and neutrophil/lymphocyte ratio (NLR). MATERIALS AND METHODS:Patients with colorectal cancer (n=20, TNM stage I, II, and III) were enrolled. Levels of nine cytokines [interleukin (IL)-4,-6, -8, -10, -12, tumor necrosis factor-alpha (TNF-α), granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon-gamma (IFN-γ), and vascular endothelial growth factor (VEGF)] were measured in serum, normal mucosa, and tumor using the Bio-Plex® cytokine assay. RESULTS: The mean IL8, GM-CSF and VEGF levels were higher in tumors, whereas the mean IL6 level was higher in serum. Cytokine levels correlated with TNM stage (IL6 and IL8 in serum, and IL8 and VEGF in tumor) and with NLR (IL6 and IL8 in serum, and IL8 in tumor). CONCLUSION: Different cytokine profiles were observed in serum, normal mucosa, and tumor tissue. The elevation of specific cytokines in sera or tumors reflects features of advanced disease. Copyright
Authors: Satoshi Matsusaka; Diana L Hanna; Shu Cao; Wu Zhang; Dongyun Yang; Yan Ning; Yu Sunakawa; Satoshi Okazaki; Martin D Berger; Yuji Miyamato; Anish Parekh; Sebastian Stintzing; Fotios Loupakis; Heinz-Josef Lenz Journal: Clin Cancer Res Date: 2016-02-02 Impact factor: 12.531
Authors: Joseph R Paonessa; Thomas Brennan; Marco Pimentel; Daniel Steinhaus; Mengling Feng; Leo Anthony Celi Journal: Crit Care Date: 2015-08-07 Impact factor: 9.097